Vogt, TPieters, RGiesy, JNewman, Brent K2020-03-192020-03-192019-01Vogta, T. et al. 2019. Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses. Marine Pollution Bulletin, vol. 138, pp. 49-570025-326X1879-3363https://doi.org/10.1016/j.marpolbul.2018.11.019https://www.sciencedirect.com/science/article/pii/S0025326X18307963?via%3Dihubhttp://hdl.handle.net/10204/11339Copyright: 2019 Elsevier. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in Marine Pollution Bulletin, vol. 138, pp. 49-57The toxic equivalences (TEQs) of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) from sediment of aquatic systems in Durban, South Africa were determined in two ways: 1) TEQs of PAHs and PCBs were determined by instrumental analyses and converted to 2,3,7,8-tetrachlorodibenzo-para-dioxin equivalence (TCDDeq). 2) Bioassay equivalences (BEQs) of aryl hydrocarbon receptor (AhR) ligands were analysed using the H4IIE-luc bioassay. TEQs of PCBs ranged from below limit of detection (<LOD) to 57 pg TCDDeq·g-1 while PAHs ranged from <LOD to 790 pg TCDDeq·g-1. BEQs were 100- to 1000-fold greater than TEQs. Potency-balance revealed <10% of the BEQs were explained by instrumentally analysed compounds. Sediment quality guidelines indicated di minimis risk relating to TEQs, however had potential risk due to BEQs. The results reveal that far more AhR ligands were present in the sediments than what was instrumentally analysed and capable of causing AhR-mediated toxicity.enAryl hydrocarbon receptorH4IIE-lucSQGsDioxinArticleVogta, T., Pieters, R., Giesy, J., & Newman, B. K. (2019). Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses. http://hdl.handle.net/10204/11339Vogta, T, R Pieters, J Giesy, and Brent K Newman "Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses." (2019) http://hdl.handle.net/10204/11339Vogta T, Pieters R, Giesy J, Newman BK. Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses. 2019; http://hdl.handle.net/10204/11339.TY - Article AU - Vogta, T AU - Pieters, R AU - Giesy, J AU - Newman, Brent K AB - The toxic equivalences (TEQs) of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) from sediment of aquatic systems in Durban, South Africa were determined in two ways: 1) TEQs of PAHs and PCBs were determined by instrumental analyses and converted to 2,3,7,8-tetrachlorodibenzo-para-dioxin equivalence (TCDDeq). 2) Bioassay equivalences (BEQs) of aryl hydrocarbon receptor (AhR) ligands were analysed using the H4IIE-luc bioassay. TEQs of PCBs ranged from below limit of detection (<LOD) to 57 pg TCDDeq·g-1 while PAHs ranged from <LOD to 790 pg TCDDeq·g-1. BEQs were 100- to 1000-fold greater than TEQs. Potency-balance revealed <10% of the BEQs were explained by instrumentally analysed compounds. Sediment quality guidelines indicated di minimis risk relating to TEQs, however had potential risk due to BEQs. The results reveal that far more AhR ligands were present in the sediments than what was instrumentally analysed and capable of causing AhR-mediated toxicity. DA - 2019-01 DB - ResearchSpace DP - CSIR KW - Aryl hydrocarbon receptor KW - H4IIE-luc KW - SQGs KW - Dioxin LK - https://researchspace.csir.co.za PY - 2019 SM - 0025-326X SM - 1879-3363 T1 - Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses TI - Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses UR - http://hdl.handle.net/10204/11339 ER -