Ndhundhuma, IHauser, CScalfi-Happ, CRück, ASteiner, R2012-02-082012-02-082011-08Ndhundhuma, I, Hauser, C, Scalfi-Happ, C et al. Subcellular co-localization of aluminum (III) phthalocyanine chloride tetrasulphonate with fluorescent markers in the human melanoma cell-line HT-144. Medical Laser Application, vol. 26(3), pp 93-1001615-1615http://www.sciencedirect.com/science/article/pii/S1615161511000263http://hdl.handle.net/10204/5552Copyright: 2011 Elsevier. This is the post-print version of the work. The definitive version is published in Medical Laser Application, vol. 26(3), pp 93-100The exposure of a photosensitizer to visible light, preferably laser light in the red region, in the presence of molecular oxygen results in a photochemical reaction described as photodynamic therapy (PDT). Photodynamic therapy is increasingly used for the treatment of skin cancers. The subcellular localization of the photosensitizer has been shown to be a key factor in the outcome of PDT. Mitochondrial localized photosensitizers are able to induce apoptosis very rapidly. Lysosomal localized photosensitizers can elicit either a necrotic or an apoptotic response. The present work contributes to the classification of the subcellular targets and cell death pathway of PDT using hydrophilic aluminum (III) phthalocyanine chloride tetrasulfonate (AlPcS4).enPhotosensitizerPhotodynamic therapyPhthalocyaninesCo-localizationLaser scanningMicroscopesArticleNdhundhuma, I., Hauser, C., Scalfi-Happ, C., Rück, A., & Steiner, R. (2011). Subcellular co-localization of aluminum (III) phthalocyanine chloride tetrasulphonate with fluorescent markers in the human melanoma cell-line HT-144. http://hdl.handle.net/10204/5552Ndhundhuma, I, C Hauser, C Scalfi-Happ, A Rück, and R Steiner "Subcellular co-localization of aluminum (III) phthalocyanine chloride tetrasulphonate with fluorescent markers in the human melanoma cell-line HT-144." (2011) http://hdl.handle.net/10204/5552Ndhundhuma I, Hauser C, Scalfi-Happ C, Rück A, Steiner R. Subcellular co-localization of aluminum (III) phthalocyanine chloride tetrasulphonate with fluorescent markers in the human melanoma cell-line HT-144. 2011; http://hdl.handle.net/10204/5552.TY - Article AU - Ndhundhuma, I AU - Hauser, C AU - Scalfi-Happ, C AU - Rück, A AU - Steiner, R AB - The exposure of a photosensitizer to visible light, preferably laser light in the red region, in the presence of molecular oxygen results in a photochemical reaction described as photodynamic therapy (PDT). Photodynamic therapy is increasingly used for the treatment of skin cancers. The subcellular localization of the photosensitizer has been shown to be a key factor in the outcome of PDT. Mitochondrial localized photosensitizers are able to induce apoptosis very rapidly. Lysosomal localized photosensitizers can elicit either a necrotic or an apoptotic response. The present work contributes to the classification of the subcellular targets and cell death pathway of PDT using hydrophilic aluminum (III) phthalocyanine chloride tetrasulfonate (AlPcS4). DA - 2011-08 DB - ResearchSpace DP - CSIR KW - Photosensitizer KW - Photodynamic therapy KW - Phthalocyanines KW - Co-localization KW - Laser scanning KW - Microscopes LK - https://researchspace.csir.co.za PY - 2011 SM - 1615-1615 T1 - Subcellular co-localization of aluminum (III) phthalocyanine chloride tetrasulphonate with fluorescent markers in the human melanoma cell-line HT-144 TI - Subcellular co-localization of aluminum (III) phthalocyanine chloride tetrasulphonate with fluorescent markers in the human melanoma cell-line HT-144 UR - http://hdl.handle.net/10204/5552 ER -