Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer

Kenyon, CPRoth, Robyn LVan der Westhuyzen, Christiaan WParkinson, CJ2012-06-132012-06-132012-03Kenyon, CP, Roth, RL, Van der Westhuyzen, CW and Parkinson, CJ. 2012. Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer. BMC Research Notes, vol. 5: 1311756-0500http://www.biomedcentral.com/1756-0500/5/131http://hdl.handle.net/10204/5900Copyright: 2011 The authors (Kenyon et al)The kinome is made up of a large number of functionally diverse enzymes, with the classification indicating very little about the extent of the conserved kinetic mechanisms associated with phosphoryl transfer. It has been demonstrated that C8-H of ATP plays a critical role in the activity of a range of kinase and synthetase enzymes.enKinase familiesPhosphoryl transferC8 protonConserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transferArticleKenyon, C., Roth, R. L., Van der Westhuyzen, C. W., & Parkinson, C. (2012). Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer. http://hdl.handle.net/10204/5900Kenyon, CP, Robyn L Roth, Christiaan W Van der Westhuyzen, and CJ Parkinson "Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer." (2012) http://hdl.handle.net/10204/5900Kenyon C, Roth RL, Van der Westhuyzen CW, Parkinson C. Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer. 2012; http://hdl.handle.net/10204/5900.TY - Article AU - Kenyon, CP AU - Roth, Robyn L AU - Van der Westhuyzen, Christiaan W AU - Parkinson, CJ AB - The kinome is made up of a large number of functionally diverse enzymes, with the classification indicating very little about the extent of the conserved kinetic mechanisms associated with phosphoryl transfer. It has been demonstrated that C8-H of ATP plays a critical role in the activity of a range of kinase and synthetase enzymes. DA - 2012-03 DB - ResearchSpace DP - CSIR KW - Kinase families KW - Phosphoryl transfer KW - C8 proton LK - https://researchspace.csir.co.za PY - 2012 SM - 1756-0500 T1 - Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer TI - Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer UR - http://hdl.handle.net/10204/5900 ER -