Motsa, Vuiswa LSeedat, NMekuto, LSekoa, P2026-07-172026-07-172026-072190-68152190-6823https://doi.org/10.1007/s13399-026-07177-9http://hdl.handle.net/10204/14853South Africa’s legalized Cannabis Sativa L. industry generates substantial biomass waste, including post-harvest materials such as stalks, leaves, roots, and seeds, as well as post-extraction residues rich in lignocellulosic components (cellulose, lignin, hemicellulose) and functional compounds (fibers, phenolic compounds, and proteins) which remain largely unvalorized. This review critically and systematically examines valorization pathways for Cannabis sativa L. biomass within the context of a circular bioeconomy, focusing on its potential as a bioresource amid South Africa’s evolving regulatory, agricultural, and industrial landscape. A systematic scoping review of 65 peer-reviewed studies (2018–2025) was conducted using international databases to evaluate biochemical and thermochemical conversion, integrated biorefinery strategies, and green extraction methods such as supercritical CO2 extraction, microwave-assisted extraction (MAE), and ultrasound-assisted extraction (UAE). Compositional analysis indicates that lignocellulosic fractions from Cannabis sativa L., particularly bast fibers and hurds, are well-suited to cascaded biorefinery applications, enabling the recovery of cannabinoids, carbon-based materials, and bioenergy. However, several challenges persist, including biomass recalcitrance to enzymatic hydrolysis, inconsistent feedstock availability, and the lack of a standardized protocol within South Africa’s regulated environment. Techno-economic assessments (TEA) highlight the need for financial incentives, decentralized infrastructure, and cohesive policies among government entities, including DALRRD, SAHPRA, and DTIC. The review proposes a South African collaboration framework linking policy with research-based process design. Key gaps include the need for life cycle assessment (LCA) and TEA validation at the pilot scale, characterization of landrace cultivars, and development of accessible pretreatment technologies for smallholders.FulltextenBiomass valorizationCannabis sativa L.Conversion technologiesCircular bioeconomyArticleN/A