Dennis, SJO'Kennedy, Maretha MRutkowska, Daria ATsekoa, Tsepo LLourens, Carina WHitzeroth, IIMeyers, AERybicki, EP2019-01-292019-01-292018-10Dennis, S.J. et al. 2018. Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses. Veterinary Research, vol. 49: https://doi.org/10.1186/s13567-018-0600-41993-54121994-4659https://doi.org/10.1186/s13567-018-0600-4https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-018-0600-4http://hdl.handle.net/10204/10648Open access article published in Veterinary Research, vol. 49: https://doi.org/10.1186/s13567-018-0600-4African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Here, we report a similar response to the vaccine in horses. This is the first report demonstrating the safety and immunogenicity of plant-produced AHS VLPs in horses.enAfrican horse sicknessAHSArticleDennis, S., O'Kennedy, M. M., Rutkowska, D. A., Tsekoa, T. L., Lourens, C. W., Hitzeroth, I., ... Rybicki, E. (2018). Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses. http://hdl.handle.net/10204/10648Dennis, SJ, Maretha M O'Kennedy, Daria A Rutkowska, Tsepo L Tsekoa, Carina W Lourens, II Hitzeroth, AE Meyers, and EP Rybicki "Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses." (2018) http://hdl.handle.net/10204/10648Dennis S, O'Kennedy MM, Rutkowska DA, Tsekoa TL, Lourens CW, Hitzeroth I, et al. Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses. 2018; http://hdl.handle.net/10204/10648.TY - Article AU - Dennis, SJ AU - O'Kennedy, Maretha M AU - Rutkowska, Daria A AU - Tsekoa, Tsepo L AU - Lourens, Carina W AU - Hitzeroth, II AU - Meyers, AE AU - Rybicki, EP AB - African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Here, we report a similar response to the vaccine in horses. This is the first report demonstrating the safety and immunogenicity of plant-produced AHS VLPs in horses. DA - 2018-10 DB - ResearchSpace DP - CSIR KW - African horse sickness KW - AHS LK - https://researchspace.csir.co.za PY - 2018 SM - 1993-5412 SM - 1994-4659 T1 - Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses TI - Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses UR - http://hdl.handle.net/10204/10648 ER -