Wang, SPanayides, Jenny-LeeRiley, DTighe, CJHii, KK2022-03-292022-03-292021-09Wang, S., Panayides, J., Riley, D., Tighe, C. & Hii, K. 2021. Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†. <i>Reaction Chemistry & Engineering, 6(11).</i> http://hdl.handle.net/10204/123592058-9883DOI: 10.1039/d1re00343ghttp://hdl.handle.net/10204/12359The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole at ambient temperature and its reaction with a range of electrophiles, achieving modest to high yields (40–94%) in short reaction times (<1 min). The method is amenable to the scale-up of this highly reactive lithio-imidazole intermediate.Abstracten2-lithio-1-(triphenylmethyl)imidazoleRapid formationPharmaceutical intermediatesArticleWang, S., Panayides, J., Riley, D., Tighe, C., & Hii, K. (2021). Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†. <i>Reaction Chemistry & Engineering, 6(11)</i>, http://hdl.handle.net/10204/12359Wang, S, Jenny-Lee Panayides, D Riley, CJ Tighe, and KK Hii "Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†." <i>Reaction Chemistry & Engineering, 6(11)</i> (2021) http://hdl.handle.net/10204/12359Wang S, Panayides J, Riley D, Tighe C, Hii K. Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†. Reaction Chemistry & Engineering, 6(11). 2021; http://hdl.handle.net/10204/12359.TY - Article AU - Wang, S AU - Panayides, Jenny-Lee AU - Riley, D AU - Tighe, CJ AU - Hii, KK AB - The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole at ambient temperature and its reaction with a range of electrophiles, achieving modest to high yields (40–94%) in short reaction times (<1 min). The method is amenable to the scale-up of this highly reactive lithio-imidazole intermediate. DA - 2021-09 DB - ResearchSpace DP - CSIR J1 - Reaction Chemistry & Engineering, 6(11) KW - 2-lithio-1-(triphenylmethyl)imidazole KW - Rapid formation KW - Pharmaceutical intermediates LK - https://researchspace.csir.co.za PY - 2021 SM - 2058-9883 T1 - Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow† TI - Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow† UR - http://hdl.handle.net/10204/12359 ER -25437