Mlalila, NSwai, HKalombo, LonjiHilonga, A2015-08-192015-08-192014-12Mlalila, N, Swai, H, Kalombo, L and Hilonga, A. 2014.Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix. Nanotechnology, Science and Applications, vol. 7, pp 105-1121177-8903http://www.dovepress.com/effects-of-spray-drying-on-wow-multiple-emulsions-prepared-from-a-stea-peer-reviewed-article-NSAhttp://hdl.handle.net/10204/8087Copyright: 2015 Dove Medical PressThe goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.enDouble emulsionsNanoparticlesPump rateSpray-dryingTestosteroneArticleMlalila, N., Swai, H., Kalombo, L., & Hilonga, A. (2014). Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix. http://hdl.handle.net/10204/8087Mlalila, N, H Swai, Lonji Kalombo, and A Hilonga "Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix." (2014) http://hdl.handle.net/10204/8087Mlalila N, Swai H, Kalombo L, Hilonga A. Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix. 2014; http://hdl.handle.net/10204/8087.TY - Article AU - Mlalila, N AU - Swai, H AU - Kalombo, Lonji AU - Hilonga, A AB - The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use. DA - 2014-12 DB - ResearchSpace DP - CSIR KW - Double emulsions KW - Nanoparticles KW - Pump rate KW - Spray-drying KW - Testosterone LK - https://researchspace.csir.co.za PY - 2014 SM - 1177-8903 T1 - Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix TI - Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix UR - http://hdl.handle.net/10204/8087 ER -