Wellington, Kevin WSteenkamp, PBrady, D2010-08-252010-08-252010-02Wellington, KW, Steenkamp, P, and Brady, D. 2010. Diamination by n-coupling using a commercial laccase. Bioorganic and Medicinal Chemistry, Vol. 18, pp 1406–14140968-0896http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TF8-4Y6450C-2-H&_cdi=5220&_user=958262&_pii=S0968089610000465&_orig=search&_coverDate=02/15/2010&_sk=999819995&view=c&wchp=dGLzVtb-zSkWb&md5=ec57bc8b705cf6773909443f2c699a0e&ie=/sdarticle.pdfhttp://hdl.handle.net/10204/4212https://www.sciencedirect.com/science/article/pii/S0968089610000465https://doi.org/10.1016/j.bmc.2010.01.025https://www.sciencedirect.com/science/article/pii/S0968089610000465Copyright: 2010 Elsevier. This is the author's accepted manuscript, the definitive version is published in the Bioorganic and Medicinal Chemistry Journal, Vol. 18(4), pp 1406–1414Nuclear diamination of p-hydrobenzoquinones with aromatic and aliphatic primary amines was catalyzed by a immobilised commercial laccase, Denilite II Base, from Novozymes. The amine and the p-hydrobenzoquinone was reacted under mild conditions (at room temperature and at 35oC in a reaction vessel open to air in the presence of laccase and a co-solvent to afford, exclusively, the diaminated pbenzoquinone. These compounds may have potential antiallergic, antibiotic, anticancer, antifungal, antiviral and 5-lipoxygenase inhibiting activity.enP-hydrobenzoquinonesGreen chemistryP-benzoquinonesBiocatalysisLaccaseDenilite baseOxidative enzymesArticleWellington, K. W., Steenkamp, P., & Brady, D. (2010). Diamination by n-coupling using a commercial laccase. http://hdl.handle.net/10204/4212Wellington, Kevin W, P Steenkamp, and D Brady "Diamination by n-coupling using a commercial laccase." (2010) http://hdl.handle.net/10204/4212Wellington KW, Steenkamp P, Brady D. Diamination by n-coupling using a commercial laccase. 2010; http://hdl.handle.net/10204/4212.TY - Article AU - Wellington, Kevin W AU - Steenkamp, P AU - Brady, D AB - Nuclear diamination of p-hydrobenzoquinones with aromatic and aliphatic primary amines was catalyzed by a immobilised commercial laccase, Denilite II Base, from Novozymes. The amine and the p-hydrobenzoquinone was reacted under mild conditions (at room temperature and at 35oC in a reaction vessel open to air in the presence of laccase and a co-solvent to afford, exclusively, the diaminated pbenzoquinone. These compounds may have potential antiallergic, antibiotic, anticancer, antifungal, antiviral and 5-lipoxygenase inhibiting activity. DA - 2010-02 DB - ResearchSpace DP - CSIR KW - P-hydrobenzoquinones KW - Green chemistry KW - P-benzoquinones KW - Biocatalysis KW - Laccase KW - Denilite base KW - Oxidative enzymes LK - https://researchspace.csir.co.za PY - 2010 SM - 0968-0896 T1 - Diamination by n-coupling using a commercial laccase TI - Diamination by n-coupling using a commercial laccase UR - http://hdl.handle.net/10204/4212 ER -