Afolayan, AJWintola, OAFouché, Gerda2017-05-162017-05-162016Afolayan, A.J., Wintola, O.A. and Fouche, G. 2016. Acute and subacute toxicological evaluation of the aerial extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar rats. Evidence-Based Complementary and Alternative Medicine, vol. 2016: Article ID 4952485. http://dx.doi.org/10.1155/2016/49524851741-4288https://www.hindawi.com/journals/ecam/2016/4952485/http://dx.doi.org/10.1155/2016/4952485http://hdl.handle.net/10204/9072Copyright © 2016 Anthony Jide Afolayan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The acute and subacute toxicity profile of the aerial extract of Monsonia angustifolia in Wistar rats was evaluated. The Organization for Economic Cooperation and Development (OECD) 420 guideline was adopted in the acute toxicity testing with a single oral dose of 5000mg/kg (b.w.). For the 28-day daily oral dosing, the extract was administered at 75, 150, and 300mg/kg b.w.; 1% ethanol in sterile distilled water was used as control. Clinical toxicity signs were subsequently evaluated. At a single dose of 5000mg/kg b.w. the extract elicited no treatment-related signs of toxicity in the animals during the 14 days of experimental period. In the subacute toxicity, there was no significant difference in hematological, renal, and liver function indices. However, dose-dependent significant increases were observed on the plasma concentrations of white blood cell and platelet counts of the treated animals compared to the control group. While cage observations revealed no treatment-facilitated signs of toxicity, histopathological examinations of the kidneys and liver also showed no obvious lesions and morphological changes. These results suggest that the extractmay be labelled and classified as safe and practically nontoxic within the doses and period of investigation in this study.enWistar ratsMonsonia angustifoliaAlternative medicineArticleAfolayan, A., Wintola, O., & Fouché, G. (2016). Acute and subacute toxicological evaluation of the aerial extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar rats. http://hdl.handle.net/10204/9072Afolayan, AJ, OA Wintola, and Gerda Fouché "Acute and subacute toxicological evaluation of the aerial extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar rats." (2016) http://hdl.handle.net/10204/9072Afolayan A, Wintola O, Fouché G. Acute and subacute toxicological evaluation of the aerial extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar rats. 2016; http://hdl.handle.net/10204/9072.TY - Article AU - Afolayan, AJ AU - Wintola, OA AU - Fouché, Gerda AB - The acute and subacute toxicity profile of the aerial extract of Monsonia angustifolia in Wistar rats was evaluated. The Organization for Economic Cooperation and Development (OECD) 420 guideline was adopted in the acute toxicity testing with a single oral dose of 5000mg/kg (b.w.). For the 28-day daily oral dosing, the extract was administered at 75, 150, and 300mg/kg b.w.; 1% ethanol in sterile distilled water was used as control. Clinical toxicity signs were subsequently evaluated. At a single dose of 5000mg/kg b.w. the extract elicited no treatment-related signs of toxicity in the animals during the 14 days of experimental period. In the subacute toxicity, there was no significant difference in hematological, renal, and liver function indices. However, dose-dependent significant increases were observed on the plasma concentrations of white blood cell and platelet counts of the treated animals compared to the control group. While cage observations revealed no treatment-facilitated signs of toxicity, histopathological examinations of the kidneys and liver also showed no obvious lesions and morphological changes. These results suggest that the extractmay be labelled and classified as safe and practically nontoxic within the doses and period of investigation in this study. DA - 2016 DB - ResearchSpace DO - 10.1155/2016/4952485 DP - CSIR KW - Wistar rats KW - Monsonia angustifolia KW - Alternative medicine LK - https://researchspace.csir.co.za PY - 2016 SM - 1741-4288 T1 - Acute and subacute toxicological evaluation of the aerial extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar rats TI - Acute and subacute toxicological evaluation of the aerial extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar rats UR - http://hdl.handle.net/10204/9072 ER -