Kenmogne, Vanelle LNweke, EETakundwa, Mutsa MFru, PNThimiri Govindaraj, Deepak B2023-04-112023-04-112022-10Kenmogne, V.L., Nweke, E., Takundwa, M.M., Fru, P. & Thimiri Govinda Raj, D.B. 2022. Application of drug repurposing-based precision medicine platform for leukaemia patient treatment. <i>Advances in Experimental Medicine and Biology.</i> http://hdl.handle.net/10204/127310065-25982214-8019https://doi.org/10.1007/5584_2022_744http://hdl.handle.net/10204/12731Drug resistance in leukaemia is a major problem that needs to be addressed. Precision medicine provides an avenue to reduce drug resistance through a personalised treatment plan. It has helped to better stratify patients based on their molecular profile and therefore improved the sensitivity of patients to a given therapeutic regimen. However, therapeutic options are still limited for patients who have already been subjected to many lines of chemotherapy. The process of designing and developing new drugs requires significant resources, including money and time. Drug repurposing has been explored as an alternative to identify effective drug(s) that could be used to target leukaemia and lessen the burden of drug resistance. The drug repurposing process usually includes preclinical studies with drug screening and clinical trials before approval. Although most of the repurposed drugs that have been identified are generally safe for leukaemia treatment, they seem not to be good candidates for monotherapy but could have value in combination with other drugs, especially for patients who have exhausted therapeutic options. In this review, we highlight precision medicine in leukaemia and the role of drug repurposing. Specifically, we discuss the several screening methods via chemoinformatic, in vitro, and ex vivo that have facilitated and accelerated the drug repurposing process.AbstractenDrug repurposingDrug screeningLeukaemiaPrecision medicineArticleKenmogne, V. L., Nweke, E., Takundwa, M. M., Fru, P., & Thimiri Govinda Raj, D. B. (2022). Application of drug repurposing-based precision medicine platform for leukaemia patient treatment. <i>Advances in Experimental Medicine and Biology</i>, http://hdl.handle.net/10204/12731Kenmogne, Vanelle L, EE Nweke, Mutsa M Takundwa, PN Fru, and Deepak B Thimiri Govinda Raj "Application of drug repurposing-based precision medicine platform for leukaemia patient treatment." <i>Advances in Experimental Medicine and Biology</i> (2022) http://hdl.handle.net/10204/12731Kenmogne VL, Nweke E, Takundwa MM, Fru P, Thimiri Govinda Raj DB. Application of drug repurposing-based precision medicine platform for leukaemia patient treatment. Advances in Experimental Medicine and Biology. 2022; http://hdl.handle.net/10204/12731.TY - Article AU - Kenmogne, Vanelle L AU - Nweke, EE AU - Takundwa, Mutsa M AU - Fru, PN AU - Thimiri Govinda Raj, Deepak B AB - Drug resistance in leukaemia is a major problem that needs to be addressed. Precision medicine provides an avenue to reduce drug resistance through a personalised treatment plan. It has helped to better stratify patients based on their molecular profile and therefore improved the sensitivity of patients to a given therapeutic regimen. However, therapeutic options are still limited for patients who have already been subjected to many lines of chemotherapy. The process of designing and developing new drugs requires significant resources, including money and time. Drug repurposing has been explored as an alternative to identify effective drug(s) that could be used to target leukaemia and lessen the burden of drug resistance. The drug repurposing process usually includes preclinical studies with drug screening and clinical trials before approval. Although most of the repurposed drugs that have been identified are generally safe for leukaemia treatment, they seem not to be good candidates for monotherapy but could have value in combination with other drugs, especially for patients who have exhausted therapeutic options. In this review, we highlight precision medicine in leukaemia and the role of drug repurposing. Specifically, we discuss the several screening methods via chemoinformatic, in vitro, and ex vivo that have facilitated and accelerated the drug repurposing process. DA - 2022-10 DB - ResearchSpace DP - CSIR J1 - Advances in Experimental Medicine and Biology KW - Drug repurposing KW - Drug screening KW - Leukaemia KW - Precision medicine LK - https://researchspace.csir.co.za PY - 2022 SM - 0065-2598 SM - 2214-8019 T1 - Application of drug repurposing-based precision medicine platform for leukaemia patient treatment TI - Application of drug repurposing-based precision medicine platform for leukaemia patient treatment UR - http://hdl.handle.net/10204/12731 ER -26363