Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte

Bode, MLGates, PJGebretnsae, SYVleggaar, R2010-11-082010-11-082010-03Bode, ML, Gates, PJ, Gebretnsae, SY and Vleggaar, R. 2010. Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte. Tetrahedron, Vol. 66(11), pp 2026-20360040-4020http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6THR-4Y65S94-6-M&_cdi=5289&_user=958262&_pii=S004040201000075X&_orig=search&_coverDate=03/13/2010&_sk=999339988&view=c&wchp=dGLbVtb-zSkWb&_valck=1&md5=e8940ee4d4fd8a01a24f0d3c9ece1c87&ie=/sdarticle.pdfhttp://hdl.handle.net/10204/4546Copyright: 2010 Elsevier. This is the authors pre print version of the work. The definitive version is published in Tetrahedron, Vol. 66(11), pp 2026-2036The structure elucidation of a novel natural product pavettamine (1), the causal agent of the plant toxicosis gousiekte, is reported. The structure was defined by analysis of NMR and MS data and the relative configuration followed from the 13C NMR data of the acetonide derivative. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology as (2S,4R,8R,10S)-1,11-diamino-6-aza-undecane-2,4,8,10-tetraol.enGousiektePavettamineStructure elucidationPolyamine synthesisStructure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekteArticleBode, M., Gates, P., Gebretnsae, S., & Vleggaar, R. (2010). Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte. http://hdl.handle.net/10204/4546Bode, ML, PJ Gates, SY Gebretnsae, and R Vleggaar "Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte." (2010) http://hdl.handle.net/10204/4546Bode M, Gates P, Gebretnsae S, Vleggaar R. Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte. 2010; http://hdl.handle.net/10204/4546.TY - Article AU - Bode, ML AU - Gates, PJ AU - Gebretnsae, SY AU - Vleggaar, R AB - The structure elucidation of a novel natural product pavettamine (1), the causal agent of the plant toxicosis gousiekte, is reported. The structure was defined by analysis of NMR and MS data and the relative configuration followed from the 13C NMR data of the acetonide derivative. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology as (2S,4R,8R,10S)-1,11-diamino-6-aza-undecane-2,4,8,10-tetraol. DA - 2010-03 DB - ResearchSpace DP - CSIR KW - Gousiekte KW - Pavettamine KW - Structure elucidation KW - Polyamine synthesis LK - https://researchspace.csir.co.za PY - 2010 SM - 0040-4020 T1 - Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte TI - Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte UR - http://hdl.handle.net/10204/4546 ER -