Sakong, BMAdenubi, OTPauw, EEloff, JNFouché, GerdaLeboho, TlaboWellington, Kevin W2017-06-072017-06-072016Fouche, G., Sakong, B.M., Adenubi, O.T. et al. 2016. Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus. Onderstepoort Journal of Veterinary Research, vol. 83(1): doi.org/10.4102/ojvr.v83i1.11640030-2465http://journals.co.za/content/opvet/83/1/EJC196363doi.org/10.4102/ojvr.v83i1.1164http://hdl.handle.net/10204/9194Copyright: © 2016. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.The nematode, Haemonchus contortus, is responsible for major economic losses in the livestock industry. The management of parasites such as H. contortus has been through the use of synthetic parasiticides. This has resulted in the presence of residues in meat and milk, which affects food safety. The development of resistance to available anthelmintics coupled with their high cost has further complicated matters. This has led to the investigation of alternative methods to manage nematodes, including the use of plants and plant extracts as a potential source of novel anthelmintics. Acetone extracts were prepared from 15 South African plant species and their anthelmintic activity determined using the egg hatch assay (EHA). The leaf extract of Cleome gynandra had the best inhibitory activity (68% ± 3%) at a concentration of 2.5 mg/mL, followed by the stem extract of Maerua angolensis (65% ± 5%). The extracts had a relatively low toxicity on Vero cells determined by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cellular assay.enLivestock productionGastrointestinal parasitesHaemonchus contortusSouth African plantsLivestock diseasesArticleSakong, B., Adenubi, O., Pauw, E., Eloff, J., Fouché, G., Leboho, T., & Wellington, K. W. (2016). Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus. http://hdl.handle.net/10204/9194Sakong, BM, OT Adenubi, E Pauw, JN Eloff, Gerda Fouché, Tlabo Leboho, and Kevin W Wellington "Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus." (2016) http://hdl.handle.net/10204/9194Sakong B, Adenubi O, Pauw E, Eloff J, Fouché G, Leboho T, et al. Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus. 2016; http://hdl.handle.net/10204/9194.TY - Article AU - Sakong, BM AU - Adenubi, OT AU - Pauw, E AU - Eloff, JN AU - Fouché, Gerda AU - Leboho, Tlabo AU - Wellington, Kevin W AB - The nematode, Haemonchus contortus, is responsible for major economic losses in the livestock industry. The management of parasites such as H. contortus has been through the use of synthetic parasiticides. This has resulted in the presence of residues in meat and milk, which affects food safety. The development of resistance to available anthelmintics coupled with their high cost has further complicated matters. This has led to the investigation of alternative methods to manage nematodes, including the use of plants and plant extracts as a potential source of novel anthelmintics. Acetone extracts were prepared from 15 South African plant species and their anthelmintic activity determined using the egg hatch assay (EHA). The leaf extract of Cleome gynandra had the best inhibitory activity (68% ± 3%) at a concentration of 2.5 mg/mL, followed by the stem extract of Maerua angolensis (65% ± 5%). The extracts had a relatively low toxicity on Vero cells determined by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cellular assay. DA - 2016 DB - ResearchSpace DP - CSIR KW - Livestock production KW - Gastrointestinal parasites KW - Haemonchus contortus KW - South African plants KW - Livestock diseases LK - https://researchspace.csir.co.za PY - 2016 SM - 0030-2465 T1 - Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus TI - Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus UR - http://hdl.handle.net/10204/9194 ER -