Mkhabela, VRay, SS2016-06-272016-06-272015-08Mkhabela, V. and Ray, S.S. 2015. Biodegradation and bioresorption of poly(-caprolactone) nanocomposite scaffolds. International Journal of Biological Macromolecules, 79, 186-1920141-8130http://www.sciencedirect.com/science/article/pii/S0141813015002949http://hdl.handle.net/10204/8589Copyright: 2015 Elsevier. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in International Journal of Biological Macromolecules, 79, 186-192A new type of hybrid three-dimensional scaffolds was prepared using poly(caprolactone) (PCL) and chitosan-modified montmorillonite by solvent casting and particulate leaching method. The scaffolds were characterized by scanning electron microscopy coupled with energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and dynamic mechanical analysis to study the structural and mechanical properties. The resulting scaffolds displayed high porosity with highly interconnected pores. EDS analysis confirmed the elemental composition of the scaffolds. The phase composition of the scaffolds was shown by XRD, which also indicated a decrease in crystallinity with the introduction of nanoclay. Biodegradability studies which were conducted in simulated physiological conditions over a period of four weeks revealed that the PCL-based scaffolds degraded by hydrolysis at a slow rate. The overall bioresorbability was also slow, with the composite-based scaffolds recording a faster rate than the neat polymer-based scaffold.enPoly(caprolactone)MontmorilloniteBiodegradabilityBioresorbabilityBiodegradation and bioresorption of poly(-caprolactone) nanocomposite scaffoldsArticleMkhabela, V., & Ray, S. (2015). Biodegradation and bioresorption of poly(-caprolactone) nanocomposite scaffolds. http://hdl.handle.net/10204/8589Mkhabela, V, and SS Ray "Biodegradation and bioresorption of poly(-caprolactone) nanocomposite scaffolds." (2015) http://hdl.handle.net/10204/8589Mkhabela V, Ray S. Biodegradation and bioresorption of poly(-caprolactone) nanocomposite scaffolds. 2015; http://hdl.handle.net/10204/8589.TY - Article AU - Mkhabela, V AU - Ray, SS AB - A new type of hybrid three-dimensional scaffolds was prepared using poly(caprolactone) (PCL) and chitosan-modified montmorillonite by solvent casting and particulate leaching method. The scaffolds were characterized by scanning electron microscopy coupled with energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and dynamic mechanical analysis to study the structural and mechanical properties. The resulting scaffolds displayed high porosity with highly interconnected pores. EDS analysis confirmed the elemental composition of the scaffolds. The phase composition of the scaffolds was shown by XRD, which also indicated a decrease in crystallinity with the introduction of nanoclay. Biodegradability studies which were conducted in simulated physiological conditions over a period of four weeks revealed that the PCL-based scaffolds degraded by hydrolysis at a slow rate. The overall bioresorbability was also slow, with the composite-based scaffolds recording a faster rate than the neat polymer-based scaffold. DA - 2015-08 DB - ResearchSpace DP - CSIR KW - Poly(caprolactone) KW - Montmorillonite KW - Biodegradability KW - Bioresorbability LK - https://researchspace.csir.co.za PY - 2015 SM - 0141-8130 T1 - Biodegradation and bioresorption of poly(-caprolactone) nanocomposite scaffolds TI - Biodegradation and bioresorption of poly(-caprolactone) nanocomposite scaffolds UR - http://hdl.handle.net/10204/8589 ER -