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Show simple item record Mlalila, N Swai, H Kalombo, Lonji Hilonga, A 2015-08-19T11:09:22Z 2015-08-19T11:09:22Z 2014-12
dc.identifier.citation Mlalila, N, Swai, H, Kalombo, L and Hilonga, A. 2014.Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix. Nanotechnology, Science and Applications, vol. 7, pp 105-112 en_US
dc.identifier.issn 1177-8903
dc.description Copyright: 2015 Dove Medical Press en_US
dc.description.abstract The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use. en_US
dc.language.iso en en_US
dc.publisher Dove Medical Press en_US
dc.relation.ispartofseries Workflow;14037
dc.subject Double emulsions en_US
dc.subject Nanoparticles en_US
dc.subject Pump rate en_US
dc.subject Spray-drying en_US
dc.subject Testosterone en_US
dc.title Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix en_US
dc.type Article en_US

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