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Show simple item record Van Heerden, FR Horak, RM Maharaj, VJ Vleggaar, R Senabe, JV Gunning, PJ 2007-06-29T08:01:26Z 2007-06-29T08:01:26Z 2007-04
dc.identifier.citation Van Heerden, FR et al. 2007. An appetite suppressant from Hoodia species. Tetrahedron Letters en
dc.identifier.issn 0040-4039
dc.description Copyright: 2007 Pergamon-Elsevier Science Ltd en
dc.description.abstract Two new pregnane glycosides were isolated by fractionation of the dried stems of Hoodia gordonii. Their structures were determined as 3beta-[beta-D-thevetopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (1) and 3beta-[beta-D-cymaropyranosyl-(1→4)-beta-D-6-deoxy-3-O-methylallopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (2) on the basis of spectroscopic studies and conversion to known compounds. Compounds 1 and 2 were also isolated from Hoodia pilifera. Compound 1 was tested for its appetite-suppressant properties in rats by oral gavage at 6.25 to 50 mg/kg and the results showed that all doses resulted in a decrease of food consumption over an eight day period and a body mass decrease when compared to the control sample receiving only the vehicle. In a comparative study against a fenfluramine control sample, compound 1 resulted in a reduction in food intake over the study period, with a concomitant overall decrease in body weight while fenfluramine resulted in a small decrease in food intake, but an increase in body weight (though less than control group) over the same period of time. en
dc.language.iso en en
dc.publisher Pergamon-Elsevier Science Ltd en
dc.subject Hoodia pilifera en
dc.subject Hoodia gordonii en
dc.subject Apocynaceae en
dc.subject Fenfluramine en
dc.subject Ghaap en
dc.subject Appetite suppressant en
dc.subject Pregnane glycoside en
dc.subject Cymarose en
dc.subject Thevetose en
dc.subject Methyl b-lilacinobioside en
dc.subject 12-O-tigloyldigipurpurogenin en
dc.title An appetite suppressant from Hoodia species en
dc.type Article en

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