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Enzymatic synthesis of 5-methyluridine by transglycosylation of guanosine and thymine

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dc.contributor.author Visser, Daniel F
dc.contributor.author Gordon, GER
dc.contributor.author Bode, ML
dc.contributor.author Mathiba, K
dc.contributor.author Brady, D
dc.date.accessioned 2013-01-30T08:05:44Z
dc.date.available 2013-01-30T08:05:44Z
dc.date.issued 2012-05
dc.identifier.citation Visser, DF, Gordon, GER, Bode, ML, Mathiba, K and Brady, D. 2012. Enzymatic synthesis of 5-methyluridine by transglycosylation of guanosine and thymine. Practical Methods for Biocatalysis and Biotransformations 2. Wiley-Blackwell. Chichester, UK, pp. 235-240 en_US
dc.identifier.isbn 978-1-119-99139-7
dc.identifier.isbn 978-1-119-94342-6
dc.identifier.uri http://onlinelibrary.wiley.com/book/10.1002/9781119943426
dc.identifier.uri http://hdl.handle.net/10204/6497
dc.description Copyright: 2012 John Wiley & Sons. This is an ABSTRACT ONLY. en_US
dc.description.abstract 5-Methyluridine (5-MU) is an intermediate in the synthesis of ß-thymidine and the antiretroviral drugs stavudine (d4T) and zidovudine (AZT)1-3. The enzymatic preparation of 5-MU involves transglycosylation4-6 and avoids the formation of unwanted isomers. The overall transglycosylation reaction effectively converts one nucleoside into another through exchange of the heterocyclic base in the presence of nucleoside phosphorylases. en_US
dc.language.iso en en_US
dc.publisher Wiley-Blackwell en_US
dc.relation.ispartofseries Workflow;5455
dc.subject Enzymatic synthesis en_US
dc.subject 5-methyluridine en_US
dc.subject Transglycosylation en_US
dc.subject Guanosine en_US
dc.subject Thymine en_US
dc.subject Enzymes en_US
dc.title Enzymatic synthesis of 5-methyluridine by transglycosylation of guanosine and thymine en_US
dc.type Book Chapter en_US


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