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dc.contributor.author Barnard, A
dc.contributor.author Msomi, S
dc.contributor.author Moolman, S
dc.contributor.author Naidoo, Kersch
dc.date.accessioned 2010-08-31T07:11:07Z
dc.date.available 2010-08-31T07:11:07Z
dc.date.issued 2010-08-31
dc.identifier.citation Barnard, A, Msomi, S, Moolman, S and Naidoo, K. 2010. Development of an oxygen carrier nanoemulsion for organ preservation. CSIR 3rd Beinnual Conference 2010, Science Real and Relevant, CSIR International Convention Center, Pretoria, South Africa, p 1 en
dc.identifier.uri http://hdl.handle.net/10204/4222
dc.description CSIR 3rd Beinnual Conference 2010, Science Real and Relevant, CSIR International Convention Center, Pretoria, South Africa en
dc.description.abstract The current key development focus in organ preservation for transplant purposes is preservation of organs at normothermic or subnormothermic temperatures (i.e at or slightly below physiological temperature) as opposed to cold storage. The current gold standard in organ preservation for transplant is to preserve harvested organs at low temperatures while circulating an organ preservation solution through the organ. The organs however, sustain some damage when exposed to such low temperatures, a phenomenon known as ‘cold perfusion damage’. It is therefore desirable to transport the organ at temperatures closer to normal physiological conditions (i.e 25 to 37 °C). This however, substantially increases the organ’s oxygen requirement levels. A critical aspect of organ preservation at higher temperatures is thus the provision of a sufficient oxygen supply to the harvested organ so that the organ can maintain its metabolic rate and remain a viable candidate for transplant. The CSIR has developed a synthetic perfluorocarbon (PFC) based nanoemulsion that serves as an oxygen carrier for the preservation of organs. Perfluorochemicals can be used as oxygen carriers due to their exceptionally high capacity to dissolve gasses1,2. Additionally, PFC’s display high levels of chemical stability and biological inertness which makes them suitable for biological use1,2. Perfluorooctyl bromide (PFOB) is the particular PFC used in the CSIR oxygen carrier emulsion1,2. en
dc.language.iso en en
dc.publisher CSIR en
dc.subject Oxygen carrier en
dc.subject Nanoemulsion en
dc.subject Organ preservation en
dc.subject CSIR Conference 2010 en
dc.title Development of an oxygen carrier nanoemulsion for organ preservation en
dc.type Poster en


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