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dc.contributor.author Pillay, P
dc.contributor.author Maharaj, V
dc.contributor.author Crouch, N
dc.contributor.author Smith, P
dc.contributor.author Lategan, C
dc.contributor.author Vleggaar, R
dc.date.accessioned 2008-12-10T11:02:29Z
dc.date.available 2008-12-10T11:02:29Z
dc.date.issued 2006-02
dc.identifier.citation Pillay, P, Maharaj, V, Crouch, N et al. 2006. Antimalarial sesquiterpene lactones from oncosiphon piluliferum. CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 27-28 February 2006, pp1 en
dc.identifier.uri http://hdl.handle.net/10204/2691
dc.description CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 27-28 February 2006 en
dc.description.abstract With the emergence and spread of drug- resistant parasites, there is a need for new chemically diverse, effective antimalarial drugs. A national multidisciplinary consortium was established to validate scientifically South African medicinal plants for the treatment of malaria. Through this consortium, an indigenous plant, Oncosiphon piluliferum, was identified as a potential source of new antimalarial drugs. Bio-assay-guided fractionation based on in vitro antiplasmodial activity led to the isolation of five sesquiterpene lactones. Spectroscopic techniques and selected derivatisations were applied to fully characterise the compounds. The five compounds and their derivatives were found to possess varying degrees of in vitro antiplasmodial activity against the D10 P. falciparum strain and to possess cytotoxicity against Chinese Hamster Ovarian (CHO) cells en
dc.language.iso en en
dc.subject Antimalarial en
dc.subject Oncosiphon piluliferum en
dc.subject South Africa en
dc.subject Sesquiterpene lactones en
dc.subject Spectroscopic techniques en
dc.subject Cytotoxicity en
dc.title Antimalarial sesquiterpene lactones from oncosiphon piluliferum en
dc.type Poster en


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