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Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method

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dc.contributor.author Latha, S
dc.contributor.author Selvamani, P
dc.contributor.author Suganya, G
dc.contributor.author Thimiri Govindaraj, Deepak
dc.contributor.author Pal, TK
dc.date.accessioned 2021-10-07T12:18:48Z
dc.date.available 2021-10-07T12:18:48Z
dc.date.issued 2021-06
dc.identifier.citation Latha, S., Selvamani, P., Suganya, G., Thimiri Govindaraj, D. & Pal, T. 2021. Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method. <i>BioNanoScience, 11.</i> http://hdl.handle.net/10204/12125 en_ZA
dc.identifier.issn 2191-1630
dc.identifier.issn 2191-1649
dc.identifier.uri https://doi.org/10.1007/s12668-021-00837-2
dc.identifier.uri http://hdl.handle.net/10204/12125
dc.description.abstract Magnetic microspheres incorporated with pantoprazole sodium—a proton pump inhibitor—were formulated by using two different polymers such as ethyl cellulose and Eudragit RS-100. The magnetic microspheres were prepared by emulsion solvent evaporation technique with different drug carrier ratio of pantoprazole: magnetite: ethyl cellulose (EC-1 = 1:1:2 and EC-2 = 1:1:4) and pantoprazole: magnetite: eudragit-RS100 (EUD-1= 1:1:2 and EUD-2 = 1:1:4). Physicochemical properties of prepared magnetic microspheres such as density of the formulated magnetic microspheres were found to be 1.32, 1.27, 1.87, and 1.53 gcm−3 for EC-1, EC-2, EUD-1, and EUD-2 respectively. Magnetic susceptibility was found to be 750, 470, 215, and 240 × 10−5 for EC-1, EC-2, EUD-1, and EUD-2. SEM proved that the formulated magnetic microspheres were smooth and spherical with the size range of 1 to 700 μm and 5 to 500 μm for ethyl cellulose and Eudragit RS-100. X-ray diffraction patterns proved that their crystalline nature of the drug in formulation was not changed. Drug release from magnetic microspheres was found to be pH dependent. The drug release from EC-1, EC-2, EUD-1, and EUD-2 was found to be 20.90%, 18.32%, 20.1%, and 13.77% w/w in pH 2; 90.71%, 78.67%, 39.03%, and 30.12% w/w in pH 7.4, and 67.61%, 57.01%, 35.16%, and 31.95% w/w in pH 8.0, respectively. Eudragit RS-100 magnetic microspheres showed controlled release of pantoprazole, when compared with ethyl cellulose formulations. en_US
dc.format Abstract en_US
dc.language.iso en en_US
dc.relation.uri https://link.springer.com/article/10.1007/s12668-021-00837-2 en_US
dc.relation.uri https://rdcu.be/cy43H en_US
dc.source BioNanoScience, 11 en_US
dc.subject Magnetic microspheres en_US
dc.subject Pantoprazole sodium en_US
dc.subject Magnetite en_US
dc.subject Ethyl cellulose en_US
dc.subject Eudragit RS-100 en_US
dc.title Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method en_US
dc.type Article en_US
dc.description.pages 643-647 en_US
dc.description.note Copyright: 2021 Springer. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website: https://doi.org/10.1007/s12668-021-00837-2 . A free fulltext non-print version of the article can be viewed at https://rdcu.be/cy43H en_US
dc.description.cluster Next Generation Health en_US
dc.description.impactarea Synthetic Nanobiotech&Biomachi en_US
dc.identifier.apacitation Latha, S., Selvamani, P., Suganya, G., Thimiri Govindaraj, D., & Pal, T. (2021). Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method. <i>BioNanoScience, 11</i>, http://hdl.handle.net/10204/12125 en_ZA
dc.identifier.chicagocitation Latha, S, P Selvamani, G Suganya, Deepak Thimiri Govindaraj, and TK Pal "Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method." <i>BioNanoScience, 11</i> (2021) http://hdl.handle.net/10204/12125 en_ZA
dc.identifier.vancouvercitation Latha S, Selvamani P, Suganya G, Thimiri Govindaraj D, Pal T. Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method. BioNanoScience, 11. 2021; http://hdl.handle.net/10204/12125. en_ZA
dc.identifier.ris TY - Article AU - Latha, S AU - Selvamani, P AU - Suganya, G AU - Thimiri Govindaraj, Deepak AU - Pal, TK AB - Magnetic microspheres incorporated with pantoprazole sodium—a proton pump inhibitor—were formulated by using two different polymers such as ethyl cellulose and Eudragit RS-100. The magnetic microspheres were prepared by emulsion solvent evaporation technique with different drug carrier ratio of pantoprazole: magnetite: ethyl cellulose (EC-1 = 1:1:2 and EC-2 = 1:1:4) and pantoprazole: magnetite: eudragit-RS100 (EUD-1= 1:1:2 and EUD-2 = 1:1:4). Physicochemical properties of prepared magnetic microspheres such as density of the formulated magnetic microspheres were found to be 1.32, 1.27, 1.87, and 1.53 gcm−3 for EC-1, EC-2, EUD-1, and EUD-2 respectively. Magnetic susceptibility was found to be 750, 470, 215, and 240 × 10−5 for EC-1, EC-2, EUD-1, and EUD-2. SEM proved that the formulated magnetic microspheres were smooth and spherical with the size range of 1 to 700 μm and 5 to 500 μm for ethyl cellulose and Eudragit RS-100. X-ray diffraction patterns proved that their crystalline nature of the drug in formulation was not changed. Drug release from magnetic microspheres was found to be pH dependent. The drug release from EC-1, EC-2, EUD-1, and EUD-2 was found to be 20.90%, 18.32%, 20.1%, and 13.77% w/w in pH 2; 90.71%, 78.67%, 39.03%, and 30.12% w/w in pH 7.4, and 67.61%, 57.01%, 35.16%, and 31.95% w/w in pH 8.0, respectively. Eudragit RS-100 magnetic microspheres showed controlled release of pantoprazole, when compared with ethyl cellulose formulations. DA - 2021-06 DB - ResearchSpace DP - CSIR J1 - BioNanoScience, 11 KW - Magnetic microspheres KW - Pantoprazole sodium KW - Magnetite KW - Ethyl cellulose KW - Eudragit RS-100 LK - https://researchspace.csir.co.za PY - 2021 SM - 2191-1630 SM - 2191-1649 T1 - Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method TI - Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method UR - http://hdl.handle.net/10204/12125 ER - en_ZA
dc.identifier.worklist 25003 en_US


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