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dc.contributor.author Aderibigbe, BA
dc.contributor.author Naki, T
dc.contributor.author Steenkamp, V
dc.contributor.author Nwamadi, M
dc.contributor.author Ray, Suprakas S
dc.contributor.author Balogun, Mohammed O
dc.contributor.author Matshe, William MR
dc.date.accessioned 2019-10-29T13:12:34Z
dc.date.available 2019-10-29T13:12:34Z
dc.date.issued 2019-09
dc.identifier.citation Aderibigbe, B.A. et al. 2019. Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy. International Journal of Polymeric Materials and Polymeric Biomaterials, pp.15 en_US
dc.identifier.issn 0091-4037
dc.identifier.issn 1563-535X
dc.identifier.uri https://doi.org/10.1080/00914037.2019.1667802
dc.identifier.uri https://www.tandfonline.com/doi/full/10.1080/00914037.2019.1667802
dc.identifier.uri http://hdl.handle.net/10204/11199
dc.description Copyright: 2019 Taylor & Francis. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. International Journal of Polymeric Materials and Polymeric Biomaterials, pp.15 en_US
dc.description.abstract Platinum-based drugs are potent anticancer drugs and are effective for the treatment of various cancers. However, they are limited pharmacologically due to toxic side effects, drug resistance and poor water solubility. In order to overcome these limitations, platinum was incorporated onto polyamidoamine carriers together with alendronate and procaine hydrochloride to form a series of conjugates. Cytotoxicity was assessed using the sulforhodamine B assay on MCF-7, MDA-MB-231 and EA.hy926 cell lines. The polymer-drug conjugates showed cytotoxicity which was selective to the cancer cell lines. The free drugs decreased cell density in all cell lines and were nonspecific. These findings indicate that the incorporation of bioactive agents onto polymers can overcome cytotoxicity associated with the drugs. The selective inhibitory effects of the conjugates towards the cancer cell lines suggest that these conjugates are potential therapeutics for combination therapy. en_US
dc.language.iso en en_US
dc.publisher Taylor & Francis en_US
dc.relation.ispartofseries Workflow;22792
dc.subject Alendronate en_US
dc.subject Cytotoxicity en_US
dc.subject Platinum en_US
dc.subject Polyamidoamine en_US
dc.subject Polymer-drug conjugates en_US
dc.subject Procaine en_US
dc.title Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy en_US
dc.type Article


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