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dc.contributor.author Alven, S
dc.contributor.author Aderibigbe, BA
dc.contributor.author Balogun, Mohammed O
dc.contributor.author Matshe, William M
dc.contributor.author Ray, Suprakas S
dc.date.accessioned 2019-08-28T07:32:39Z
dc.date.available 2019-08-28T07:32:39Z
dc.date.issued 2019-10
dc.identifier.citation Alven, S., Aderibigbe, B.A., Balogun, M.O., Matshe, W.M. & Ray, S.S. 2019. Polymer-drug conjugates containing antimalarial drugs and antibiotics. Journal of Drug Delivery Science and Technology, Vol, 53, pp. 1-12. en_US
dc.identifier.issn 1773-2247
dc.identifier.uri https://doi.org/10.1016/j.jddst.2019.101171
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S1773224719307622
dc.identifier.uri http://hdl.handle.net/10204/11109
dc.description Copyright: 2019 Elsevier. Due to copyright restrictions, the attached PDF file contains the abstract version of the full-text item. For access to the full-text item, please consult the publisher's website. The definitive version of the work is published in the Journal of Drug Delivery Science and Technology, Vol, 53, pp. 1-12. https://doi.org/10.1016/j.jddst.2019.101171 en_US
dc.description.abstract Most of the currently used antimalarial drugs suffer from drug resistance, poor bioavailability and biodegradability, drug toxicity and poor water solubility. To overcome some of the aforementioned limitations, combination therapy involving the combination of two or more antimalarials is currently used. Malaria is also treated by combining selected antibiotics with antimalarials resulting in good treatment outcomes. In this research, the aforementioned approach was employed by developing polymer-drug conjugates incorporated with antimalarials and antibiotics for a synergistic effect. The successful incorporation of antimalarials and antibiotics onto the polyaspartamide-based conjugates was confirmed by 1H NMR, FTIR and SEM. The XRD spectrums displayed the amorphous nature of the conjugates and indicated the absence of free drugs. The antiplasmodial evaluation of the conjugates further revealed their antimalarial activity against the asexual stage of the parasite with a % inhibition in the range of 35.6–99.9 at 1 μM, and 55.4–100.8 at 5 μM which was either comparable or better than the free drugs. The incorporation of the antibiotics together with the antimalarials into the polymer revealed a synergistic effect indicating that antibiotics act as a potentiating agent. However, more research is needed to confirm these findings. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Workflow;22624
dc.subject Antimalarials en_US
dc.subject Combination therapy en_US
dc.subject Polymer-drug conjugates en_US
dc.subject Primaquine en_US
dc.subject Sulfadoxine en_US
dc.subject Pyrimethamine en_US
dc.subject 4-Aminosalicylic acid en_US
dc.title Polymer-drug conjugates containing antimalarial drugs and antibiotics en_US
dc.type Article en_US


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