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Browsing Book Chapters by Subject "5-methyluridine"
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Item Enzymatic synthesis of 5-methyluridine by transglycosylation of guanosine and thymine(Wiley-Blackwell, 2012-05) Visser, Daniel F; Gordon, GER; Bode, ML; Mathiba, K; Brady, D5-Methyluridine (5-MU) is an intermediate in the synthesis of ß-thymidine and the antiretroviral drugs stavudine (d4T) and zidovudine (AZT)1-3. The enzymatic preparation of 5-MU involves transglycosylation4-6 and avoids the formation of unwanted isomers. The overall transglycosylation reaction effectively converts one nucleoside into another through exchange of the heterocyclic base in the presence of nucleoside phosphorylases.