Journal Articles
Permanent URI for this collection
Browse
Browsing Journal Articles by Subject "1,3-ß-glucan"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
Item Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages(Springer, 2018-06) Tukulula, M; Gouveia, L; Paixao, P; Hayeshi, R; Naicker, Brendon; Dube, AMycobacterium tuberculosis which causes tuberculosis, is primarily resident within macrophages. 1,3-ß-glucan has been proposed as a ligand to target drug loaded nanoparticles (NPs) to macrophages. In this study we characterized the intracellular pharmacokinetics of the anti-tubercular drug rifampicin delivered by 1,3-ß-glucan functionalized PLGA NPs (Glu-PLGA). We hypothesized that Glu-PLGA NPs would be taken up at a faster rate than PLGA NPs, and consequently deliver higher amounts of rifampicin into the macrophages.