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Browsing Book Chapters by Author "Aderibigbe, B"
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Item Bionanopolymers for drug delivery(Springer, 2019-07) Fasiku, VO; Owonubi, SJ; Mukwevho, E; Aderibigbe, B; Sadiku, E; Lemmer, Yolandy; Reddy, AB; Manjula, B; Nkuna, C; Dludlu, MKIn medicine, the need and demand for the successful delivery of pharmacologically active materials or therapeutic compounds to cells, tissues, and organs in the system have made drug delivery techniques broadly studied. Several drug delivery methods have been developed and investigated in the past. The aim is to design better approaches to treat various diseases affecting humans in the world. This has led to the development and use of different materials of natural and synthetic origin as drug delivery devices. However, certain limitations and challenges have been faced with the use of most of these materials hence the need for more suitable alternatives. Some of these limitations include material toxicity, non-biocompatibility, and nonflexibility among others. At the moment, research has brought to limelight some group of materials with unique properties that can potentially serve as drug delivery systems. They are commonly referred to as biopolymers and because they can be manipulated, they can be fabricated into nanosizes (sizes of between 1 and 100 nm); hence, they are called bionanopolymers. Bionanopolymers are generally of natural origin, they are biodegradable and biocompatible. These properties have made them widely employed in biomedical applications. Bionanopolymers have gained attention in drug delivery and have contributed to the progress recorded in the treatment of disease conditions such as cancer, diabetes, allergy, infection, and inflammation.Item Graphene-based materials for implants(Wiley, 2019-06) Fasiku, F; Owonubi, S; Mukwevho, E; Aderibigbe, B; Sadiku, E; Lemmer, YolandyOver the years, many different materials, e.g., titanium (Ti) and its alloys, have been used in biomedicine for several purposes. A common application of such materials is seen in their usage as implants. However, quite a number of graphene-based materials have emerged and developed from a two dimensional single atomic thick block of a carbon allotrope, known as graphene. Since the discovery and isolation of graphene from graphite in the year 2004, there has been tremendous positive improvement in health conditions which require treatments that involves the use of implants. World-wide, this has led to significant attention and appreciation of this versatile material, in biomedicine and obviously, in all fields of science and engineering. Examples of some of the graphene-based materials to be discussed, include: reduced graphene oxide (rGO) and graphite oxide (GO). Although, graphene-based materials are distinguishable by their individual and unique properties, nevertheless, they still have certain characteristics in common. Owing to these properties, possessed by different graphene-based materials, they are able to serve in the biomedical field as implants in order to combat a wide range of diseases that have been a challenge, previously. This chapter elaborates on some different graphenebased materials, in respect to their: structures, synthesis, properties, advantages and disadvantages and the applications of these materials as implants in biomedicine.