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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/968

Title: Haemozoin (B-haematin) biomineralization occurs by self-assembly near the lipid/water interface
Authors: Egan, TJ
Chen, JY-J
De Villiers, KA
Mabotha, TE
Naidoo, KJ
Ncokazi, KK
Langford, SJ
McNaughton, D
Pandiancherri, S
Wood, BR
Keywords: Malaria
Lipids
Haemozoin
Issue Date: Sep-2006
Publisher: Elsevier B.V
Citation: Egan, TJ, et al. 2006. Haemozoin (B-haematin) biomineralization occurs by self-assembly near the lipid/water interface. FEBS Letters, Vol. 580(21), pp 5105-5110
Abstract: Several blood-feeding organisms, including the malaria parasite detoxify haem released from host haemoglobin by conversion to the insoluble crystalline ferriprotoporphyrin IX dimer known as haemozoin. To date the mechanism of haemozoin formation has remained unknown, although lipids or proteins have been suggested to catalyse its formation. We have found that B-haematin (synthetic haemozoin) forms rapidly under physiologically realistic conditions near octanol/water, pentanol/water and lipid/water interfaces. Molecular dynamics simulations show that a precursor of the haemozoin dimer forms spontaneously in the absence of the competing hydrogen bonds of water, demonstrating that this substance probably self-assembles near a lipid/water interface in vivo.
Description: Copyright: 2006 Elsevier Science B.V
URI: http://hdl.handle.net/10204/968
ISSN: 0031-0182
Appears in Collections:High performance computing
General science, engineering & technology

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