• Mycobacterium komaniense sp. nov., a rapidly growing nontuberculous Mycobacterium species detected in South Africa 

  Gcebe, N; Rutten, VPMG; Gey van Pittius, N; Naicker, Brendon; Michel, AL (Microbiology Society, 2018-03)

  Some species of non-tuberculous mycobacteria (NTM) have been reported to be opportunistic pathogens of animals and humans. Recently there has been an upsurge in the number of cases of NTM infections, such that some NTM ...
• Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages 

  Tukulula, M; Gouveia, L; Paixao, P; Hayeshi, R; Naicker, Brendon; Dube, A (Springer, 2018-06)

  Mycobacterium tuberculosis which causes tuberculosis, is primarily resident within macrophages. 1,3-ß-glucan has been proposed as a ligand to target drug loaded nanoparticles (NPs) to macrophages. In this study we characterized ...
• Characterisation of African elephant beta casein and its relevance to the chemistry of caseins and casein micelles 

  Madende, M; Kemp, G; Stoychev, Stoyan H; Osthoff, G (2018-10)
• Stability and structural properties of gene regulation networks with coregulation rules 

  Warrell, Jonathan; Mhlanga, Musa (Elsevier, 2017-05)

  Coregulation of the expression of groups of genes has been extensively demonstrated empirically in bacterial and eukaryotic systems. Such coregulation can arise through the use of shared regulatory motifs, which allow the ...
• Lnc-ing inflammation to disease 

  Magagula, L; Gagliardi, M; Naidoo, Jerolen; Mhlanga, Musa (Portland Press LTD, 2017-08)

  Termed 'master gene regulators' long ncRNAs (lncRNAs) have emerged as the true vanguard of the 'noncoding revolution'. Functioning at a molecular level, in most if not all cellular processes, lncRNAs exert their effects ...
• Mycobacterium malmesburyense sp. nov., a non-tuberculous species of the genus Mycobacterium revealed by multiple gene sequence characterization 

  Gcebe, N; Rutten, V; Gey van Pittius, N; Naicker, Brendon; Michel, A (Microbiology Society, 2017-04)

  Non-tuberculous mycobacteria (NTM) are ubiquitous in the environment, and an increasing number of NTM species have been isolated and characterized from both humans and animals, highlighting the zoonotic potential of these ...
• A high speed OCT system developed at the CSIR National Laser Centre 

  Sharma, Ameeth (South African Institute of Physics (SAIP), 2016-07)

  Light based techniques continue to gain momentum in different spheres of diagnostic and therapeutic applications as a result of their non-invasive, noncontact properties. One such technique is Optical Coherence tomography ...
• Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti 

  Scholefield, Janine; Henriques, R; Savulescu, AF; Fontan, E; Boucharlat, A; Laplantine, E; Smahi, A; Israel, A; Agou, F; Mhlanga, Musa (Nature, 2016-09)

  The NF- B pathway has critical roles in cancer, immunity and inflammatory responses. Understanding the mechanism(s) by which mutations in genes involved in the pathway cause disease has provided valuable insight into its ...
• Losing the boxes: fragmentation as a source of system complexity 

  Baumbach, J; Marais, Andre H; Gonçalves, DP (International Council on Systems Engineering South Africa, 2015-09)

  Despite the advances in mature engineering disciplines, some complex systems continue to fail, and sometimes catastrophically. The lack of understanding of a problem and all its constituting elements is a key determinant ...
• Proton induced X-ray emission and electron microscopy analysis of induced mutants of sorghum 

  Mbambo, Z; Minnis-Ndimba, R; Pineda, C; Ndimba, B; Bado, S; Lin, J; Chikwamba, Rachel K; Mehlo, L (Wageningen Academic Publishers, 2014)

  Gamma irradiation induced alterations in the spatial distribution and localization profiles of Fe, Zn, K, P, Cl, Ca, S, Mn, and Cu in mutant seeds of sorghum were determined using PIXE. The changes included enhanced or ...
• The effect of solar irradiated Vibrio cholera on the secretion of pro-inflammatory cytokines and chemokines by the JAWS II dendritic cell line in vitro 

  Ssemakalu, CC; Ubomba-Jaswa, Eunice; Motaung, KS; Pillay, M (Public Library of Science, 2015-06)

  The use of solar irradiation to sterilize water prior to its consumption has resulted in the reduction of water related illnesses in waterborne disease endemic communities worldwide. Currently, research on solar water ...
• Evidence of novel plant-species specific ammonia oxidizing bacterial clades in acidic South African fynbos soils 

  Ramond, JB; Lako, JDW; Stafford, William HL; Tuffin, MI; Cowan, DA (Wiley-VCH Verlag, 2015-02)

  Ammonia-oxidizing bacteria (AOB) are essential in the biogeochemical cycling of nitrogen as they catalyze the rate-limiting oxidation of ammonia into nitrite. Since their first isolation in the late 19th century, ...
• Systems biology tools to understand the role of host miRNAs in infection: a closer look at HIV 

  Naidoo, J; Brackin, R; Khutlang, Rethabile; Savulescu, A; Mhlanga, Musa (Caister Academic Press, 2014-06)

  The discovery of mammalian microRNAs (miRNAs) has greatly enhanced our appreciation for the complexity associated with the regulation of the mammalian transcriptional landscape. Endogenous miRNA pathways mediate the targeted ...
• Comparison of two detection algorithms for spot tracking in fluorescence microscopy images 

  Mabaso, M; Withey, Daniel J; Twala, B (PRASA, 2014-11)

  Research in biological image analysis plays an important role in understanding the underlying mechanisms of cellular processes, which may lead to better knowledge of certain aspects of the cell function. The primary analysis ...
• Graphene for improved femtosecond laser based pluripotent stem cell transfection 

  Mthunzi, P; He, K; Ngcobo, S; Khanyile, T; Warner, JH (Wiley-VCH Verlag, 2014-05)

  Pluripotent stem cells are hugely attractive in the tissue engineering research field as they can self-renew and be selectively differentiated into various cell types. For stem cell and tissue engineering research it is ...
• The potential for a fish ladder to mitigate against the loss of marine-estuarine-freshwater connectivity in a subtropical coastal lake 

  Weerts, Steven P; MacKay, CF; Cyrus, DP (Water Research Commission, 2014-01)

  Increasing water demand in coastal regions has resulted in the construction of weirs and barrages in coastal freshwaters. These form barriers to migrations of estuarine and euryhaline marine fishes and crustaceans. This ...
• Super-resolution post-processing for satellites with yaw-steering capability 

  Van den Dool, R; Van der Walt, S (Academia, 2012-10)

  We describe a method for improving Earth observation satellite image resolution, for specific areas of interest where the sensor design resolution is insufficient. Our method may be used for satellites with yaw-steering ...
• Defining pyromes and global syndromes of fire regimes 

  Archibald, S; Lehmann, CER; Gómez-Dans, JL; Bradstock, RA (National Academy of Sciences, 2013-04)

  Fire is a ubiquitous component of the Earth system that is poorly understood. To date, a global-scale understanding of fire is largely limited to the annual extent of burning as detected by satellites. This is problematic ...
• The fire-vegetation-climate system: how ecology can contribute to earth system science 

  Archibald, S (Elsevier, 2013-05)

  Since the time of Darwin, Wallace and Schimper, botanists and ecologists have been interested in understanding the global distribution of vegetation. Such questions are becoming more pressing as Earth System modellers ...
• The soil and plant determinants of community structures of the dominant actinobacteria in Marion Island terrestrial habitats, Sub-Antarctica 

  Sanyika, TW; Stafford, William HL; Cowan, DA (Springer Verlag, 2012-08)

  Marion Island is a Sub-Antarctic island made up of distinct ecological habitats based on soil physiochemical, plant cover and physical characteristics. The microbial diversity and ecological determinants in this harsh ...

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