Noninvasive Micromanipulation of Live HIV-1 Infected Cells via Laser Light

Abstract

Live mammalian cells from various tissues of origin can be aseptically and noninvasively micromanipulated via lasers of different regimes. Laser-driven techniques are therefore paving a path toward the advancement of human immunodeficiency virus (HIV-1) investigations. Studies aimed at the interaction of laser light, nanomaterials, and biological materialscan also lead to an understanding of a wealth of disease conditions and result in photonics-based therapies and diagnostic tools. Thus, in the authors' research, both continuous wave and pulsed lasers operated at varying wavelengths are employed, as they possess special properties that allow classical biomedical applications. This paper discusses photo-translocation of antiretroviral drugs into HIV-1 permissive cells and preliminary results of low-level laser therapy (LLLT) in HIV-1 infected cells.