dc.contributor.author |
Van Heerden, FR
|
|
dc.contributor.author |
Horak, RM
|
|
dc.contributor.author |
Maharaj, VJ
|
|
dc.contributor.author |
Vleggaar, R
|
|
dc.contributor.author |
Senabe, JV
|
|
dc.contributor.author |
Gunning, PJ
|
|
dc.date.accessioned |
2007-06-29T08:01:26Z |
|
dc.date.available |
2007-06-29T08:01:26Z |
|
dc.date.issued |
2007-04 |
|
dc.identifier.citation |
Van Heerden, FR et al. 2007. An appetite suppressant from Hoodia species. Tetrahedron Letters |
en |
dc.identifier.issn |
0040-4039 |
|
dc.identifier.uri |
http://hdl.handle.net/10204/765
|
|
dc.description |
Copyright: 2007 Pergamon-Elsevier Science Ltd |
en |
dc.description.abstract |
Two new pregnane glycosides were isolated by fractionation of the dried stems of Hoodia gordonii. Their structures were determined as 3beta-[beta-D-thevetopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (1) and 3beta-[beta-D-cymaropyranosyl-(1→4)-beta-D-6-deoxy-3-O-methylallopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (2) on the basis of spectroscopic studies and conversion to known compounds. Compounds 1 and 2 were also isolated from Hoodia pilifera. Compound 1 was tested for its appetite-suppressant properties in rats by oral gavage at 6.25 to 50 mg/kg and the results showed that all doses resulted in a decrease of food consumption over an eight day period and a body mass decrease when compared to the control sample receiving only the vehicle. In a comparative study against a fenfluramine control sample, compound 1 resulted in a reduction in food intake over the study period, with a concomitant overall decrease in body weight while fenfluramine resulted in a small decrease in food intake, but an increase in body weight (though less than control group) over the same period of time. |
en |
dc.language.iso |
en |
en |
dc.publisher |
Pergamon-Elsevier Science Ltd |
en |
dc.subject |
Hoodia pilifera |
en |
dc.subject |
Hoodia gordonii |
en |
dc.subject |
Apocynaceae |
en |
dc.subject |
Fenfluramine |
en |
dc.subject |
Ghaap |
en |
dc.subject |
Appetite suppressant |
en |
dc.subject |
Pregnane glycoside |
en |
dc.subject |
Cymarose |
en |
dc.subject |
Thevetose |
en |
dc.subject |
Methyl b-lilacinobioside |
en |
dc.subject |
12-O-tigloyldigipurpurogenin |
en |
dc.title |
An appetite suppressant from Hoodia species |
en |
dc.type |
Article |
en |
dc.identifier.apacitation |
Van Heerden, F., Horak, R., Maharaj, V., Vleggaar, R., Senabe, J., & Gunning, P. (2007). An appetite suppressant from Hoodia species. http://hdl.handle.net/10204/765 |
en_ZA |
dc.identifier.chicagocitation |
Van Heerden, FR, RM Horak, VJ Maharaj, R Vleggaar, JV Senabe, and PJ Gunning "An appetite suppressant from Hoodia species." (2007) http://hdl.handle.net/10204/765 |
en_ZA |
dc.identifier.vancouvercitation |
Van Heerden F, Horak R, Maharaj V, Vleggaar R, Senabe J, Gunning P. An appetite suppressant from Hoodia species. 2007; http://hdl.handle.net/10204/765. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Van Heerden, FR
AU - Horak, RM
AU - Maharaj, VJ
AU - Vleggaar, R
AU - Senabe, JV
AU - Gunning, PJ
AB - Two new pregnane glycosides were isolated by fractionation of the dried stems of Hoodia gordonii. Their structures were determined as 3beta-[beta-D-thevetopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (1) and 3beta-[beta-D-cymaropyranosyl-(1→4)-beta-D-6-deoxy-3-O-methylallopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (2) on the basis of spectroscopic studies and conversion to known compounds. Compounds 1 and 2 were also isolated from Hoodia pilifera. Compound 1 was tested for its appetite-suppressant properties in rats by oral gavage at 6.25 to 50 mg/kg and the results showed that all doses resulted in a decrease of food consumption over an eight day period and a body mass decrease when compared to the control sample receiving only the vehicle. In a comparative study against a fenfluramine control sample, compound 1 resulted in a reduction in food intake over the study period, with a concomitant overall decrease in body weight while fenfluramine resulted in a small decrease in food intake, but an increase in body weight (though less than control group) over the same period of time.
DA - 2007-04
DB - ResearchSpace
DP - CSIR
KW - Hoodia pilifera
KW - Hoodia gordonii
KW - Apocynaceae
KW - Fenfluramine
KW - Ghaap
KW - Appetite suppressant
KW - Pregnane glycoside
KW - Cymarose
KW - Thevetose
KW - Methyl b-lilacinobioside
KW - 12-O-tigloyldigipurpurogenin
LK - https://researchspace.csir.co.za
PY - 2007
SM - 0040-4039
T1 - An appetite suppressant from Hoodia species
TI - An appetite suppressant from Hoodia species
UR - http://hdl.handle.net/10204/765
ER -
|
en_ZA |