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Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin

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dc.contributor.author Van der Westhuyzen, Christiaan W
dc.contributor.author Parkinson, CJ
dc.date.accessioned 2007-06-29T08:00:26Z
dc.date.available 2007-06-29T08:00:26Z
dc.date.issued 2005
dc.identifier.citation Van der Westhuyzen, CW and Parkinson, CJ. 2005. Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin. South African Journal of Chemistry, vol. 58, pp 41-45 en
dc.identifier.issn 0379-4350
dc.identifier.uri http://hdl.handle.net/10204/763
dc.description Copyright: 2005 Bureau Scientific Publications en
dc.description.abstract Alpha-Santonin 3 was successfully converted into a biologically active compound 5b containing an endoperoxide group through a photo-oxygenation approach as a single isomer. It was found that the singlet oxygen afforded the isomer produced by attack from the sterically-hindered face of cyclohexadiene derivative 4. Evidence to this end is presented based on NOE results and the products formed in the photo-oxygenation reaction, as well as the in vitro testing of 5b for antimalarial activity. en
dc.language.iso en en
dc.publisher Bureau Scientific Publications en
dc.subject Singlet oxygen en
dc.subject Santonin en
dc.subject Photo-oxygenated en
dc.subject Endoperoxide en
dc.title Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin en
dc.type Article en
dc.identifier.apacitation Van der Westhuyzen, C. W., & Parkinson, C. (2005). Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin. http://hdl.handle.net/10204/763 en_ZA
dc.identifier.chicagocitation Van der Westhuyzen, Christiaan W, and CJ Parkinson "Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin." (2005) http://hdl.handle.net/10204/763 en_ZA
dc.identifier.vancouvercitation Van der Westhuyzen CW, Parkinson C. Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin. 2005; http://hdl.handle.net/10204/763. en_ZA
dc.identifier.ris TY - Article AU - Van der Westhuyzen, Christiaan W AU - Parkinson, CJ AB - Alpha-Santonin 3 was successfully converted into a biologically active compound 5b containing an endoperoxide group through a photo-oxygenation approach as a single isomer. It was found that the singlet oxygen afforded the isomer produced by attack from the sterically-hindered face of cyclohexadiene derivative 4. Evidence to this end is presented based on NOE results and the products formed in the photo-oxygenation reaction, as well as the in vitro testing of 5b for antimalarial activity. DA - 2005 DB - ResearchSpace DP - CSIR KW - Singlet oxygen KW - Santonin KW - Photo-oxygenated KW - Endoperoxide LK - https://researchspace.csir.co.za PY - 2005 SM - 0379-4350 T1 - Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin TI - Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin UR - http://hdl.handle.net/10204/763 ER - en_ZA


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