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dc.contributor.author Adekanmi, AE
dc.contributor.author Fouché, Gerda
dc.contributor.author Steenkamp, V
dc.date.accessioned 2012-11-27T07:45:54Z
dc.date.available 2012-11-27T07:45:54Z
dc.date.issued 2012-09
dc.identifier.citation Adekanmi, AE, Fouche, G and Steenkamp, V. 2012. Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae). Journal of Ethnopharmacology, vol. 143(2), pp 572-578 en_US
dc.identifier.issn 0378-8741
dc.identifier.issn 1872-7573
dc.identifier.uri http://www.sciencedirect.com/science/article/pii/S0378874112004801
dc.identifier.uri http://hdl.handle.net/10204/6381
dc.description Copyright: 2012 Elsevier. All rights reserved. This is the author’s version of the work. The definitive version is published in Journal of Ethnopharmacology, vol 143, issue 2, September 2012, pp 572-578, doi:10.1016/j.jep.2012.07.011. en_US
dc.description.abstract Boophane disticha of the family Amaryllidaceae is used traditionally by the indigenous people of southern Africa in the treatment of several neurological disorders. Weak decoctions of bulb scales are given to sedate violent, psychotic patients while bulb infusions are reported to be used to treat mental illness. The present study describes for the first time, the isolation of 6-hydroxycrinamine, a crinine alkaloid, from the methanol extract of the bulbs of Boophane disticha. Although this compound possessed activity, it was found to be toxic to the neuroblastoma cells. Quantitative structure-activity relationship studies could be carried out to modify the structure in order to make it less toxic and improve its activity. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Workflow;9241
dc.subject Acetylcholinesterase en_US
dc.subject Amaryllidaceae en_US
dc.subject Boophane disticha en_US
dc.subject Cytotoxicity en_US
dc.subject SH-SY5Y cells en_US
dc.subject 6-hydroxycrinamine en_US
dc.title Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae) en_US
dc.type Article en_US


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