DSpace
 

Researchspace >
General science, engineering & technology >
General science, engineering & technology >
General science, engineering & technology >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/6381

Title: Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae)
Authors: Adekanmi, AE
Fouche, G
Steenkamp, V
Keywords: Acetylcholinesterase
Amaryllidaceae
Boophane disticha
Cytotoxicity
SH-SY5Y cells
6-hydroxycrinamine
Issue Date: Sep-2012
Publisher: Elsevier
Citation: Adekanmi, AE, Fouche, G and Steenkamp, V. 2012. Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae). Journal of Ethnopharmacology, vol. 143(2), pp 572-578
Series/Report no.: Workflow;9241
Abstract: Boophane disticha of the family Amaryllidaceae is used traditionally by the indigenous people of southern Africa in the treatment of several neurological disorders. Weak decoctions of bulb scales are given to sedate violent, psychotic patients while bulb infusions are reported to be used to treat mental illness. The present study describes for the first time, the isolation of 6-hydroxycrinamine, a crinine alkaloid, from the methanol extract of the bulbs of Boophane disticha. Although this compound possessed activity, it was found to be toxic to the neuroblastoma cells. Quantitative structure-activity relationship studies could be carried out to modify the structure in order to make it less toxic and improve its activity.
Description: Copyright: 2012 Elsevier. All rights reserved. This is the author’s version of the work. The definitive version is published in Journal of Ethnopharmacology, vol 143, issue 2, September 2012, pp 572-578, doi:10.1016/j.jep.2012.07.011.
URI: http://www.sciencedirect.com/science/article/pii/S0378874112004801
http://hdl.handle.net/10204/6381
ISSN: 0378-8741
1872-7573
Appears in Collections:General science, engineering & technology
Bioprospecting
General research interest
Discovery chemistry

Files in This Item:

File Description SizeFormat
Adekanmi_2012.pdf1.35 MBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback