The term “nucleic acid therapy” encompasses a wide range of technologies for the treatment of a range of plant and animal ailments. As the name implies, it makes use of nucleic acid (either DNA or RNA) as a therapeutic agent. There are six branches namely: antisense, ribozymes, RNA/DNA decoys, triplex forming oligonucleotides (TFO), RNA interference (RNAi) and most recently aptamers. These therapies work by modulating gene expression of either endogenous or invading genes. This review will provide a brief history of each of the technologies as well as an insight into the potential way forward.
Reference:
Millroy, L. Nucleic Acid Therapy: from humble beginnings a dynamic technology. EMBO global exchange lecture course on HIV AIDS, Stellenbosch, 30 January 2011 - 4 February 2011
Millroy, L. (2011). Nucleic Acid Therapy: from humble beginnings a dynamic technology. http://hdl.handle.net/10204/6338
Millroy, L. "Nucleic Acid Therapy: from humble beginnings a dynamic technology." (2011): http://hdl.handle.net/10204/6338
Millroy L, Nucleic Acid Therapy: from humble beginnings a dynamic technology; 2011. http://hdl.handle.net/10204/6338 .
