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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/6313

Title: Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus
Authors: London, GG
Madiga, MM
Gray, EE
Sok, DD
Morris, LL
Burton, DD
Khati, MM
Keywords: Human immunodeficiency virus type-I
HIV-1 subtype C
2'F-RNA Aptamers
Envelope pseudovirus
Issue Date: Sep-2012
Publisher: BioMed Central
Citation: London, GG, Madiga, MM, Gray, EE, Sok, DD, Morris, LL, Burton, DD and Khati, MM. 2012. Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus. Retrovirology, vol. 9 (supplement 2), p. 222
Series/Report no.: Workflow;9653
Abstract: Human immunodeficiency virus type-I (HIV-1) envelope glycoprotein (Env) mediates the first step of entry and represents an attractive target . However, the genetic diversity of Env among HIV-1 subtypes poses a challenge. Although evidence suggest that entry inhibitors in clinical use have comparable efficacy against HIV-1 subtypes, but a subset of anti-Env are resistant to HIV-1 subtype C which is the most globally prevalent virus. In a view to prevent infection of HIV-1 subtype C, we isolated nucleic acids ligands aptamers against HIV-1 subtype C Env pseudovirion and tested their efficacy.
Description: Copyright: 2012 London et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://www.retrovirology.com/content/pdf/1742-4690-9-S2-P222.pdf
ISSN: 1742-4690
Appears in Collections:Accessibility research
Advanced mathematical modelling and simulation
General science, engineering & technology

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