Human immunodeficiency virus type-I (HIV-1) envelope glycoprotein (Env) mediates the first step of entry and represents an attractive target . However, the genetic diversity of Env among HIV-1 subtypes poses a challenge. Although evidence suggest that entry inhibitors in clinical use have comparable efficacy against HIV-1 subtypes, but a subset of anti-Env are resistant to HIV-1 subtype C which is the most globally prevalent virus. In a view to prevent infection of HIV-1 subtype C, we isolated nucleic acids ligands aptamers against HIV-1 subtype C Env pseudovirion and tested their efficacy.
Reference:
London, GG, Madiga, MM, Gray, EE, Sok, DD, Morris, LL, Burton, DD and Khati, MM. 2012. Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus. Retrovirology, vol. 9 (supplement 2), p. 222
London, G., Madiga, M., Gray, E., Sok, D., Morris, L., Burton, D., & Khati, M. (2012). Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus. http://hdl.handle.net/10204/6313
London, GG, MM Madiga, EE Gray, DD Sok, LL Morris, DD Burton, and MM Khati "Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus." (2012) http://hdl.handle.net/10204/6313
London G, Madiga M, Gray E, Sok D, Morris L, Burton D, et al. Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus. 2012; http://hdl.handle.net/10204/6313.
Copyright: 2012 London et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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