DSpace
 

Researchspace >
General science, engineering & technology >
General science, engineering & technology >
General science, engineering & technology >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/5632

Title: Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy
Authors: Nombona, N
Maduray, K
Antunes, E
Karsten, A
Nyokong, T
Keywords: Phthalocyanine
Gold nanoparticles
Liposomes
Photodynamic therapy
Issue Date: Feb-2012
Publisher: Elsevier
Citation: Nombona, N, Maduray, K, Antunes, E, Karsten, A and Nyokong, T. 2012. Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology, vol. 107, pp 35-44
Series/Report no.: Workflow;8321
Abstract: The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5 J cm-2. The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement in PDT activity.
Description: Copyright: 2012 Elsevier. This is an ABSTRACT ONLY
URI: http://www.sciencedirect.com/science/article/pii/S101113441100251X
http://hdl.handle.net/10204/5632
ISSN: 1011-1344
Appears in Collections:Laser physics and technology
General science, engineering & technology
Discovery chemistry

Files in This Item:

File Description SizeFormat
Karsten1_2011_ABSTRACT ONLY.pdf223.95 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback