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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/5414

Title: PALM and STORM: unlocking live-cell super-resolution
Authors: Henriques, R
Griffiths, C
Rego, EH
Mhlanga, MM
Keywords: Super-resolution
Microscopy methods
Single molecules
Live-cell imaging
Super-resolution microscopy
Issue Date: May-2011
Publisher: Wiley Blackwell
Citation: Henriques, R, Griffiths, C et al. 2011. PALM and STORM: unlocking live-cell super-resolution. Biopolymers, Vol 95(5), pp 322-331
Series/Report no.: Workflow request;6582
Abstract: Live-cell fluorescence light microscopy has emerged as an important tool in the study of cellular biology. The development of fluorescent markers in parallel with super-resolution imaging systems has pushed light microscopy into the realm of molecular visualization at the nanometer scale. Resolutions previously only attained with electron microscopes are now within the grasp of light microscopes. However, until recently, live-cell imaging approaches have eluded super-resolution microscopy, hampering it from reaching its full potential for revealing the dynamic interactions in biology occurring at the single molecule level. Here we examine recent advances in the super-resolution imaging of living cells by reviewing recent breakthroughs in single molecule localization microscopy methods such as PALM and STORM to achieve this important goal.
Description: Copyright: 2011 Wiley Blackwell. This is an ABSTRACT ONLY
URI: http://onlinelibrary.wiley.com/doi/10.1002/bip.21586/abstract
ISSN: 0006-3525
Appears in Collections:Sustainability science
Water resources and human health
Structural biology
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Systems biology
General science, engineering & technology

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