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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/4546

Title: Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte
Authors: Bode, ML
Gates, PJ
Gebretnsae, SY
Vleggaar, R
Keywords: Gousiekte
Pavettamine
Structure elucidation
Polyamine synthesis
Issue Date: Mar-2010
Citation: Bode, ML, Gates, PJ, Gebretnsae, SY and Vleggaar, R. 2010. Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte. Tetrahedron, Vol. 66(11), pp 2026-2036
Series/Report no.: Journal Article
Abstract: The structure elucidation of a novel natural product pavettamine (1), the causal agent of the plant toxicosis gousiekte, is reported. The structure was defined by analysis of NMR and MS data and the relative configuration followed from the 13C NMR data of the acetonide derivative. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology as (2S,4R,8R,10S)-1,11-diamino-6-aza-undecane-2,4,8,10-tetraol.
Description: Copyright: 2010 Elsevier. This is the authors pre print version of the work. The definitive version is published in Tetrahedron, Vol. 66(11), pp 2026-2036
URI: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6THR-4Y65S94-6-M&_cdi=5289&_user=958262&_pii=S004040201000075X&_orig=search&_coverDate=03/13/2010&_sk=999339988&view=c&wchp=dGLbVtb-zSkWb&_valck=1&md5=e8940ee4d4fd8a01a24f0d3c9ece1c87&ie=/sdarticle.pdf
http://hdl.handle.net/10204/4546
ISSN: 0040-4020
Appears in Collections:General science, engineering & technology
Discovery chemistry

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