DSpace
 

Researchspace >
General science, engineering & technology >
General science, engineering & technology >
General science, engineering & technology >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/4286

Title: Lipid containing nanodrug delivery system for the treatment of Tuberculosis
Authors: Lemmer, Y
Semete, B
Kalombo, L
Ramalapa, B
Jones, AT
Swai, HS
Verschoor, JA
Keywords: Lipids
Nanodrugs
Tuberculosis
CSIR Conference 2010
Mycobacterium tuberculosis
Issue Date: 1-Sep-2010
Publisher: CSIR
Citation: Lemmer, Y, Semete, B, Kalombo, L et al. 2010. Lipid containing nanodrug delivery system for the treatment of Tuberculosis. CSIR 3rd Biennial Conference 2010. Science Real and Relevant. CSIR International Convention Centre, Pretoria, South Africa, 30 August – 01 September 2010, pp 1
Abstract: Challenges in treatment of Tuberculosis (TB) include non-specific localisation of the drugs which results in too low concentrations of the drugs reaching the target site of infection, thus leading to reduced effectiveness. To improve the current inadequate therapeutic management of TB, a polymeric nanodrug delivery system, for anti-TB drugs was developed by a double emulsion evaporation technique. The system could enable entry, targeting, sustained release for longer periods and uptake of the antibiotics in the cells, hence reducing the dose frequency and simultaneously improve patient compliance. The cell wall envelope of Mycobacterium tuberculosis (M.tb) contains unique high molecular weight lipids. Of these, the most abundant are mycolic acids (MA), an extended family of long 2-alkyl 3-hydroxyl fatty acids, typically 70-90 carbon atoms in length, with peculiar physical and biological properties. MA have further been shown to have a similarity in the structural properties with cholesterol1. MA were explored as the targeting agent to infected macrophages containing abundance of cholesterol.
Description: CSIR 3rd Biennial Conference 2010. Science Real and Relevant. CSIR International Convention Centre, Pretoria, South Africa, 30 August – 01 September 2010
URI: http://hdl.handle.net/10204/4286
Appears in Collections:Polymers and composites
CSIR Conference 2010
Nanotechnology
Polymers and bioceramics
General science, engineering & technology

Files in This Item:

File Description SizeFormat
Lemmer_2010_P.pdf677.44 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback