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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/4222

Title: Development of an oxygen carrier nanoemulsion for organ preservation
Authors: Barnard, A
Msomi, S
Moolman, S
Naidoo, K
Keywords: Oxygen carrier
Nanoemulsion
Organ preservation
CSIR Conference 2010
Issue Date: 31-Aug-2010
Publisher: CSIR
Citation: Barnard, A, Msomi, S, Moolman, S and Naidoo, K. 2010. Development of an oxygen carrier nanoemulsion for organ preservation. CSIR 3rd Beinnual Conference 2010, Science Real and Relevant, CSIR International Convention Center, Pretoria, South Africa, p 1
Abstract: The current key development focus in organ preservation for transplant purposes is preservation of organs at normothermic or subnormothermic temperatures (i.e at or slightly below physiological temperature) as opposed to cold storage. The current gold standard in organ preservation for transplant is to preserve harvested organs at low temperatures while circulating an organ preservation solution through the organ. The organs however, sustain some damage when exposed to such low temperatures, a phenomenon known as ‘cold perfusion damage’. It is therefore desirable to transport the organ at temperatures closer to normal physiological conditions (i.e 25 to 37 °C). This however, substantially increases the organ’s oxygen requirement levels. A critical aspect of organ preservation at higher temperatures is thus the provision of a sufficient oxygen supply to the harvested organ so that the organ can maintain its metabolic rate and remain a viable candidate for transplant. The CSIR has developed a synthetic perfluorocarbon (PFC) based nanoemulsion that serves as an oxygen carrier for the preservation of organs. Perfluorochemicals can be used as oxygen carriers due to their exceptionally high capacity to dissolve gasses1,2. Additionally, PFC’s display high levels of chemical stability and biological inertness which makes them suitable for biological use1,2. Perfluorooctyl bromide (PFOB) is the particular PFC used in the CSIR oxygen carrier emulsion1,2.
Description: CSIR 3rd Beinnual Conference 2010, Science Real and Relevant, CSIR International Convention Center, Pretoria, South Africa
URI: http://hdl.handle.net/10204/4222
Appears in Collections:CSIR Conference 2010
Nanotechnology
General science, engineering & technology

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