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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/4212

Title: Diamination by n-coupling using a commercial laccase
Authors: Wellington, KW
Steenkamp, P
Brady, D
Keywords: P-hydrobenzoquinones
Green chemistry
Denilite base
Oxidative enzymes
Issue Date: Feb-2010
Publisher: Elsevier
Citation: Wellington, KW, Steenkamp, P, and Brady, D. 2010. Diamination by n-coupling using a commercial laccase. Bioorganic and Medicinal Chemistry, Vol. 18, pp 1406–1414
Abstract: Nuclear diamination of p-hydrobenzoquinones with aromatic and aliphatic primary amines was catalyzed by a immobilised commercial laccase, Denilite II Base, from Novozymes. The amine and the p-hydrobenzoquinone was reacted under mild conditions (at room temperature and at 35oC in a reaction vessel open to air in the presence of laccase and a co-solvent to afford, exclusively, the diaminated pbenzoquinone. These compounds may have potential antiallergic, antibiotic, anticancer, antifungal, antiviral and 5-lipoxygenase inhibiting activity.
Description: Copyright: 2010 Elsevier. This is the author's accepted manuscript, the definitive version is published in the Bioorganic and Medicinal Chemistry Journal, Vol. 18(4), pp 1406–1414
URI: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TF8-4Y6450C-2-H&_cdi=5220&_user=958262&_pii=S0968089610000465&_orig=search&_coverDate=02/15/2010&_sk=999819995&view=c&wchp=dGLzVtb-zSkWb&md5=ec57bc8b705cf6773909443f2c699a0e&ie=/sdarticle.pdf
ISSN: 0968-0896
Appears in Collections:Enzyme technologies
General science, engineering & technology

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