Novel electrochemical sensors based on carbon paste impregnated with metallopthalocyanine (MPc, M¼Co, Fe) complexes, have been constructed for the assay of anti-HIV drug 2’,3’-dideoxyinosine (didanosine, DDI). Both modified electrodes showed electrocatalytic activity towards the oxidation of dideoxyinosine in phosphate buffer pH 7.4 with a working concentration range of 10-6–10-4 mol/L and a detection limit of 10-7 mol/L magnitude order. The sensor proved to be highly reliable for the assay of the purity of DDI - raw material as well as for the uniformity content test of Videx tablets.
Reference:
Ozoemena, KI, Stefan-van Staden, RI and Nyokong, T. 2009. Metallophthalocyanine based carbon paste electrodes for the determination of 2’,3’-Dideoxyinosine. Electroanalysis, Vol. 21(14). pp 1651- 1654
Ozoemena, K., Stefan-van Staden, R., & Nyokong, T. (2009). Metallophthalocyanine based carbon paste electrodes for the determination of 2’,3’-Dideoxyinosine. http://hdl.handle.net/10204/3589
Ozoemena, KI, RI Stefan-van Staden, and T Nyokong "Metallophthalocyanine based carbon paste electrodes for the determination of 2’,3’-Dideoxyinosine." (2009) http://hdl.handle.net/10204/3589
Ozoemena K, Stefan-van Staden R, Nyokong T. Metallophthalocyanine based carbon paste electrodes for the determination of 2’,3’-Dideoxyinosine. 2009; http://hdl.handle.net/10204/3589.
Copyright: 2009 Wiley-VCH Verlag. This is the author's version of the work. It is posted here by permission of Wiley-VCH Verlag for your personal use. Not for redistribution. The definitive version was published in the journal, Electroanalysis, Vol. 21(14). pp 1651- 1654
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