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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/3387

Title: Design, scale up and safe piloting of thymol hydrogenation and menthol racemisation
Authors: Dudas, J
Hanika, J
Keywords: Thymol hydrogenation
Menthol racemisation
l-menthol
Enzymes
Trickle-bed reactor
Gas-liquid-solid reaction
Chemical engineering
Issue Date: Jan-2009
Publisher: Elsevier
Citation: Dudas, J and Hanika, J. 2009. Design, scale up and safe piloting of thymol hydrogenation and menthol racemisation. Chemical Engineering Research and Design, Vol. (2009), pp 1-33
Abstract: The hydrogenation of thymol and the racemisation of a menthol mixture were investigated as part of the development of novel process for the production of l-menthol. The key innovation in this l-menthol process is the enzymatic resolution of l -menthol from 8 menthol isomers mixture. The productivity of the enzyme (mass of l-mentylacetate produced/mass enzyme) is a key performance measurement of this process. The demonstration of the required enzyme productivity was therefore a key objective of the process piloting. The effect of possible side products and impurities on the process also needed to be tested and therefore five cycles of piloting were performed using approximately 500 kg of feed into resolution in each cycle. The required quantities of the menthol mixture were obtained in pilot plant trickle bed reactor
Description: Author Posting. Copyright Elsevier, 2009. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution
URI: http://hdl.handle.net/10204/3387
ISSN: 0263-8762
Appears in Collections:Microbial expression systems
Enzyme technologies
General science, engineering & technology

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