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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/3369

Title: Emulsion preparation for novel micro-porous polymeric hemi-shells
Authors: Naidoo, K
Rolfes, H
Easton, K
Moolman, S
Chetty, A
Richter, W
Nilen, R
Keywords: Novel micro-porous polymeric hemi-shells
Hemi-shells
PCL
Porogen
Issue Date: 2008
Publisher: Elsevier
Citation: Naidoo, K et al. 2008. Emulsion preparation for novel micro-porous polymeric hemi-shells. Materials Letters, Vol. 62, pp 252-254
Abstract: A modified oil-in-water (O/W) emulsion process was developed to produce novel micro-porous hemi-spherical polycaprolactone (PCL) micro-particles called "hemi-shells". By addition of a porogen such as sodium bicarbonate (NaHCO3) into the PCL-dichloromethane (DCM) oil phase and emulsification in an acidic polyvinyl alcohol (PVA) aqueous phase, micro-porous hemi-shells formed as solvent evaporated. CO2 gas evolution from the porogen created particles with an externally micro-porous shell and a large internal cavity. The hemi-shells were characterized by SEM and optical microscopy. The number-average particle yield in the 50-200 µm range was 84%. The number-average hemi-shell yield in the same size range was 41%. These novel micro-particles have potential applications in tissue engineering and drug delivery
Description: Copyroght: 2007 Elsevier
URI: http://hdl.handle.net/10204/3369
ISSN: 0167-577X
Appears in Collections:General science, engineering & technology

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