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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/3368

Title: Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment
Authors: Boca, MB
Pretorius, E
Kgaje, CG
Apostolides, Z
Keywords: Micellar electrokinetic chromatography
MEKC
Pharmaceutical manufacturing equipment
Active pharmaceutical ingredients
APIs
Drug residue
Sulfamethoxazole
SMZ
Trimethoprim
TMP
Issue Date: Mar-2008
Publisher: Elsevier
Citation: Boca, MB, Pretorius, E, Kgaje, CG and Apostolides, Z. 2008. Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment. Journal of Pharmaceutical and Biomedical Analysis, Vol. 46(4), pp 1-13
Abstract: The suitability of micellar electrokinetic chromatography for the simultaneous trace determination of several compounds (sulfamethoxazole, trimethoprim, sulfanilic acid, sulfanilamide, 3,4,5-trimethoxybenzoic acid and nonoxynol-9) was assessed. The mixture was separated within 14 minutes at an applied voltage of 22 kV by using 30 mM phosphate electrolyte, containing 10 mM SDS, adjusted to pH 7.8. Under optimized separation conditions acceptable levels of linearity, precision and accuracy were obtained for all compounds. The method could be used as part of a cleaning validation study when assaying trace levels of co-trimoxazole drug, some of its decomposition products and detergent in the swab samples collected from pharmaceutical manufacturing equipment, after cleaning
Description: Author Posting. Copyright Elsevier, 2008. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution
URI: http://hdl.handle.net/10204/3368
ISSN: 0731-7085
Appears in Collections:General science, engineering & technology
Discovery chemistry

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