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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/3354

Title: Green chemistry: highly selective biocatalytic hydrolysis of nitrile compounds
Authors: Brady, D
Dube, N
Petersen, RL
Keywords: Green chemistry
Biocatalytic hydrolysis
Nitrile compounds
Hydrolytic enzymes
Bacteria
Yeast
Nitriles
Issue Date: Sep-2006
Publisher: Academy of Science of South Africa
Citation: Brady, D, Dube, N and Petersen, RL. 2006. Green chemistry: highly selective biocatalytic hydrolysis of nitrile compounds. South African Journal of Science, Vol.(2006), pp 1-18
Abstract: The application of highly substrate-specific catalysts, such as biocatalysts, can reduce the number of synthetic steps required to generate organic compounds. A wide range of bacteria and yeast cultures were enriched on nitriles as the sole source of nitrogen and evaluated for their substrate profiles. The substrates included aliphatic and aromatic nitriles, as well as structurally related amides. Small-scale liquid reactions were monitored using high pressure liquid chromatography and gas chromatography, combined with mass spectroscopy. The microbial biocatalysts demonstrated a wide variation of activities between genera, within genera, and even within species. The range of substrates transformed and the inter- and intra-species differences in specificity of the individual biocatalysts, suggests that it is possible to provide multiple catalytic or bioremediation agents for the fine chemicals industry
Description: This is the author's version of the work. It is posted here by permission of the Academy of Science of South Africa for your personal use. Not for redistribution
URI: http://hdl.handle.net/10204/3354
ISSN: 1819-3595
Appears in Collections:Pollution and waste
Yeast expression systems
General science, engineering & technology
Discovery chemistry

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