Formation of an interpolymer complex in supercritical carbon dioxide and its application in the encapsulation of probiotics

Abstract

Traditional encapsulation methods present difficulties for sensitive actives such as probiotics, due to exposure to water/solvents, heat, oxygen, etc. The authors present a novel encapsulation technology utilising the formation of an interpolymer complex in a supercritical carbon dioxide environment. Interpolymer complex formation was confirmed through FTIR and moisture absorption studies. Polymer liquefaction and release of encapsulated probiotics were studied with SEM. Indomethacin and B. longum were encapsulated using the method, with poly(vinyl pyrrolidone) and poly(vinyl acetate-co-crotonic acid) as interpolymer complex. The polymer system provides protection at low pH, while releasing at higher pH. Potential applications include encapsulation of sensitive actives in the food and pharmaceutical industry