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Surface coated polyurethane with improved bioactivity and cytocompatability

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dc.contributor.author Chetty, AS
dc.contributor.author Seynberg, TJ
dc.contributor.author Moolman, FS
dc.contributor.author Nilen, RWN
dc.contributor.author Joubert, AM
dc.contributor.author Richter, PW
dc.date.accessioned 2008-12-08T13:43:24Z
dc.date.available 2008-12-08T13:43:24Z
dc.date.issued 2006-02
dc.identifier.citation Chetty, AS, Seynberg, TJ, Moolman, FS et al. 2006. Surface coated polyurethane with improved bioactivity and cytocompatability. CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 26-27 February 2006, pp1 en
dc.identifier.uri http://hdl.handle.net/10204/2677
dc.description CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 26-27 February 2006 en
dc.description.abstract Polyurethane (PU) may be suitable for various implant applications; however, it lacks bioactivity. Bioactivity allows for direct tissue attachment at the bio- interface, enabling implant fixation while preventing fibrous encapsulation. To impart bioactivity, PU was coated with a layer of hydroxyapatite (HA) by a solvent- compression method. Bioactivity of the HA- coated PU substrates was demonstrated by incubation in simulated body fluid (SBF) for up to nine days. Using crystal violet DNA staining and MTT (3- [4,5 dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide) assay for determining the cell number and cell metabolic activity respectively, cytocompatibility of the HA-coated PU substrates was demonstrated towards a number of cell lines. The HA-coated PU substrates prepared in this study could find application where non- resorbable biomaterials are required, including cartilage replacement, maxillofacial implants, ID tags and biosensors en
dc.language.iso en en
dc.subject Biomaterials en
dc.subject Polyurethane en
dc.subject Hydroxyapatiteep en
dc.subject Cytocompatibility en
dc.title Surface coated polyurethane with improved bioactivity and cytocompatability en
dc.type Conference Presentation en
dc.identifier.apacitation Chetty, A., Seynberg, T., Moolman, F., Nilen, R., Joubert, A., & Richter, P. (2006). Surface coated polyurethane with improved bioactivity and cytocompatability. http://hdl.handle.net/10204/2677 en_ZA
dc.identifier.chicagocitation Chetty, AS, TJ Seynberg, FS Moolman, RWN Nilen, AM Joubert, and PW Richter. "Surface coated polyurethane with improved bioactivity and cytocompatability." (2006): http://hdl.handle.net/10204/2677 en_ZA
dc.identifier.vancouvercitation Chetty A, Seynberg T, Moolman F, Nilen R, Joubert A, Richter P, Surface coated polyurethane with improved bioactivity and cytocompatability; 2006. http://hdl.handle.net/10204/2677 . en_ZA
dc.identifier.ris TY - Conference Presentation AU - Chetty, AS AU - Seynberg, TJ AU - Moolman, FS AU - Nilen, RWN AU - Joubert, AM AU - Richter, PW AB - Polyurethane (PU) may be suitable for various implant applications; however, it lacks bioactivity. Bioactivity allows for direct tissue attachment at the bio- interface, enabling implant fixation while preventing fibrous encapsulation. To impart bioactivity, PU was coated with a layer of hydroxyapatite (HA) by a solvent- compression method. Bioactivity of the HA- coated PU substrates was demonstrated by incubation in simulated body fluid (SBF) for up to nine days. Using crystal violet DNA staining and MTT (3- [4,5 dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide) assay for determining the cell number and cell metabolic activity respectively, cytocompatibility of the HA-coated PU substrates was demonstrated towards a number of cell lines. The HA-coated PU substrates prepared in this study could find application where non- resorbable biomaterials are required, including cartilage replacement, maxillofacial implants, ID tags and biosensors DA - 2006-02 DB - ResearchSpace DP - CSIR KW - Biomaterials KW - Polyurethane KW - Hydroxyapatiteep KW - Cytocompatibility LK - https://researchspace.csir.co.za PY - 2006 T1 - Surface coated polyurethane with improved bioactivity and cytocompatability TI - Surface coated polyurethane with improved bioactivity and cytocompatability UR - http://hdl.handle.net/10204/2677 ER - en_ZA


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