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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/2677

Title: Surface coated polyurethane with improved bioactivity and cytocompatability
Authors: Chetty, AS
Seynberg, TJ
Moolman, FS
Nilen, RWN
Joubert, AM
Richter, PW
Keywords: Biomaterials
Polyurethane
Hydroxyapatiteep
Cytocompatibility
Issue Date: Feb-2006
Citation: Chetty, AS, Seynberg, TJ, Moolman, FS et al. 2006. Surface coated polyurethane with improved bioactivity and cytocompatability. CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 26-27 February 2006, pp1
Abstract: Polyurethane (PU) may be suitable for various implant applications; however, it lacks bioactivity. Bioactivity allows for direct tissue attachment at the bio- interface, enabling implant fixation while preventing fibrous encapsulation. To impart bioactivity, PU was coated with a layer of hydroxyapatite (HA) by a solvent- compression method. Bioactivity of the HA- coated PU substrates was demonstrated by incubation in simulated body fluid (SBF) for up to nine days. Using crystal violet DNA staining and MTT (3- [4,5 dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide) assay for determining the cell number and cell metabolic activity respectively, cytocompatibility of the HA-coated PU substrates was demonstrated towards a number of cell lines. The HA-coated PU substrates prepared in this study could find application where non- resorbable biomaterials are required, including cartilage replacement, maxillofacial implants, ID tags and biosensors
Description: CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 26-27 February 2006
URI: http://hdl.handle.net/10204/2677
Appears in Collections:CSIR Conference 2006
General science, engineering & technology

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