dc.contributor.author |
Pillay, P
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dc.contributor.author |
Naidoo, Dashnie
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dc.contributor.author |
Maharaj, VJ
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dc.contributor.author |
Moodley, N
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dc.contributor.author |
Sewnarain, P
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dc.contributor.author |
Van Rooyen, S
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dc.contributor.author |
Mthembu, X
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dc.contributor.author |
Khorombi, E
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dc.date.accessioned |
2008-11-13T08:33:09Z |
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dc.date.available |
2008-11-13T08:33:09Z |
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dc.date.issued |
2008-11 |
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dc.identifier.citation |
Pillay, P, Naidoo, D, Maharaj, VJ et al. 2008. South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV. Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17&18 November 2008, pp 4 |
en |
dc.identifier.uri |
http://hdl.handle.net/10204/2540
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dc.description |
Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17&18 November 2008 |
en |
dc.description.abstract |
CSIR Biosciences is actively involved in identifying new medicines effective against tuberculosis (TB), malaria and HIV based on South Africa’s rich biodiversity. As part of a national multidisciplinary consortium, the Bioprospecting research group and the South African National Biodiversity Institute (SANBI) established a database of 566 plant taxa that are reportedly used for the treatment of TB and 623 taxa associated with malaria and/or fever. A process of prioritization using selection criteria led to 162 plant extracts, representing 24 taxa, being tested in a preliminary in vitro screen against Mycobacterium aurum. Thirteen extracts demonstrated significant antibacterial activity and were subsequently tested against M. tuberculosis. This led to 7 extracts (5 taxa) with significant anti- TB activity. Of the 134 plant taxa tested for in vitro antimalarial activity against a chloroquine-sensitive strain of Plasmodium falciparum, 23 species were found to be highly active. Bioprospecting has screened 30 plants with traditional use related to the treatment of HIV for their anti-HIV properties, resulting in the identification of four biologically active plant extracts (4 taxa), which are currently being further developed. A recent research collaboration with Esperanza Medicines Foundation (EMF) also provided a unique opportunity to evaluate South African medicinal plants in HIV/AIDS-related biological assays exclusive to the Swiss-based institute. Overall, compelling evidence has been provided for the rational exploration of South African plants as sources of new drugs to treat TB, malaria and HIV |
en |
dc.language.iso |
en |
en |
dc.subject |
Infectious diseases |
en |
dc.subject |
Malaria |
en |
dc.subject |
Tuberculosis |
en |
dc.subject |
HIV |
en |
dc.subject |
Plant extracts |
en |
dc.subject |
Drug |
en |
dc.title |
South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV. |
en |
dc.type |
Conference Presentation |
en |
dc.identifier.apacitation |
Pillay, P., Naidoo, D., Maharaj, V., Moodley, N., Sewnarain, P., Van Rooyen, S., ... Khorombi, E. (2008). South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV. http://hdl.handle.net/10204/2540 |
en_ZA |
dc.identifier.chicagocitation |
Pillay, P, Dashnie Naidoo, VJ Maharaj, N Moodley, P Sewnarain, S Van Rooyen, X Mthembu, and E Khorombi. "South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV." (2008): http://hdl.handle.net/10204/2540 |
en_ZA |
dc.identifier.vancouvercitation |
Pillay P, Naidoo D, Maharaj V, Moodley N, Sewnarain P, Van Rooyen S, et al, South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV; 2008. http://hdl.handle.net/10204/2540 . |
en_ZA |
dc.identifier.ris |
TY - Conference Presentation
AU - Pillay, P
AU - Naidoo, Dashnie
AU - Maharaj, VJ
AU - Moodley, N
AU - Sewnarain, P
AU - Van Rooyen, S
AU - Mthembu, X
AU - Khorombi, E
AB - CSIR Biosciences is actively involved in identifying new medicines effective against tuberculosis (TB), malaria and HIV based on South Africa’s rich biodiversity. As part of a national multidisciplinary consortium, the Bioprospecting research group and the South African National Biodiversity Institute (SANBI) established a database of 566 plant taxa that are reportedly used for the treatment of TB and 623 taxa associated with malaria and/or fever. A process of prioritization using selection criteria led to 162 plant extracts, representing 24 taxa, being tested in a preliminary in vitro screen against Mycobacterium aurum. Thirteen extracts demonstrated significant antibacterial activity and were subsequently tested against M. tuberculosis. This led to 7 extracts (5 taxa) with significant anti- TB activity. Of the 134 plant taxa tested for in vitro antimalarial activity against a chloroquine-sensitive strain of Plasmodium falciparum, 23 species were found to be highly active. Bioprospecting has screened 30 plants with traditional use related to the treatment of HIV for their anti-HIV properties, resulting in the identification of four biologically active plant extracts (4 taxa), which are currently being further developed. A recent research collaboration with Esperanza Medicines Foundation (EMF) also provided a unique opportunity to evaluate South African medicinal plants in HIV/AIDS-related biological assays exclusive to the Swiss-based institute. Overall, compelling evidence has been provided for the rational exploration of South African plants as sources of new drugs to treat TB, malaria and HIV
DA - 2008-11
DB - ResearchSpace
DP - CSIR
KW - Infectious diseases
KW - Malaria
KW - Tuberculosis
KW - HIV
KW - Plant extracts
KW - Drug
LK - https://researchspace.csir.co.za
PY - 2008
T1 - South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV
TI - South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV
UR - http://hdl.handle.net/10204/2540
ER -
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en_ZA |