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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/1515

Title: Hydrolytic kinetic resolution of the enantiomers of the structural isomers trans-1-phenylpropene oxide and (2,3-epoxypropyl) benzene by yeast epoxide hydrolase
Authors: Lotter, J
Botes, AL
Dyk, MS
Breytenbach, JC
Keywords: Biotransformations
Epoxide hydrolases
Kinetic resolutions
Issue Date: Aug-2004
Publisher: Kluwer Academic Publisher
Citation: Lotter, J, et al. 2004. Hydrolytic kinetic resolution of the enantiomers of the structural isomers trans-1-phenylpropene oxide and (2,3-epoxypropyl) benzene by yeast epoxide hydrolase. Biotechology Letters, vol 26 (15), pp 1197-1200
Abstract: Kinetic resolution of the enantiomers of trans-1-phenylpropene oxide and (2,3-epoxypropyl)benzene was achieved by yeasts from the genus Rhodotorula. The resolution of trans-1-phenylpropene oxide by Rhodotorula glutinis UOFS Y-0123 yielded (1R, 2R)-epoxide (ee >98%, yield 30%) and (1R, 2S)-diol (ee 95%, yield 40%). The highest enantio- and region selectivity toward (2,3-epoxypropyl)benzene resided in Rhodotorula sp. UOFS Y-0448 (E = 6.16), yielding (S)-epoxide (ee 64%, yield 33%) and (R)-diol (ee 67%, yield 28%). This confirms the superiority of yeasts from the Basidiomycetes genera in the enantio selective hydrolysis of epoxides from different structural classes.
URI: http://hdl.handle.net/10204/1515
http://hdl.handle.net/10204/1515
ISSN: 0141-5492
Appears in Collections:General science, engineering & technology
Bioprospecting

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