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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/1395

Title: In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa
Authors: Clarkson, C
Maharaj, VJ
Crouch, NR
Grace, WM
Pillay, P
Matsabisa, MG
Bhagwandin, N
Smith, PJ
Folb, PI
Keywords: Malaria
In-vitro antiplasmodial activities
Plasmodium falciparum
Ethnomedicinal plants
South Africa
Plant sciences
Pharmacology
Issue Date: Jun-2004
Publisher: Elsevier Science Ireland Ltd
Citation: Clarkson, C, et al. 2004. In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. Journal of Ethnopharmacology, vol 92, 03 February, pp 177-191.
Abstract: The increasing prevalence and distribution of malaria has been attributed to a number of factors, one of them being the emergence and spread of drug resistant parasites. Efforts are now being directed towards the discovery and development of new chemically diverse antimalarial agents. The present study reports on the in vitro antiplasmodial activity of 134 plant taxa native to or naturalised in South Africa, representing 54 families, which were selected semi-quantitatively using weighted criteria. The plant extracts were tested for in vitro activity against a Plasmodium falciparum strain D10 using the parasite lactate dehydrogenase (pLDH) assay. Of the 134 species assayed, 49% showed promising antiplasmodial activity (IC50 less or equal to 10_g/ml), while 17% were found to be highly active (IC50 less or equal to 5_g/ml). Several plant species and genera were shown for the first time to possess in vitro antiplasmodial activity. These results support a rational rather than random approach to the selection of antiplasmodial screening candidates, and identify a number of promising taxa for further investigation as plant-based antimalarial agents.
URI: http://hdl.handle.net/10204/1395
http://hdl.handle.net/10204/1395
ISSN: 0378-8741
Appears in Collections:General science, engineering & technology
Bioprospecting
Agroprocessing and chemical technology

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